He appeared on Room 101 in 2005, while Paul Merton was host, successfully banishing the Royal Variety Performance and the British honours system into Room 101, saying that he would never accept an honour himself. In 2013 he clarified that position, stating that he had "no fundamental objection to the honours system", and that he selected the honours system for Room 101 because he could "tell funny stories about it".
Brandreth hosts an annual Oscar Wilde party to celebrate the writer's birth. Guests have included Stephen Fry, Joanna Lumley, Derek Jacobi, Julian Fellowes and Camilla, Duchess of Cornwall The venues are often places of interest in Wilde's life, for example the Langham Hotel where A Picture of Dorian Gray was commissioned. In August 2005, he appeared in a production of Shakespeare's Twelfth Night at the Edinburgh Festival.