James has donated to both Republican and Democratic politicians and institutions. He was a major Republican donor from 2000 - 2008, and even gave slightly more to Republicans than Democrats in the 2008 presidential election. He contributed about $130,890 to Republicans in the Bush era. Under President George W. Bush, James served as a member of the President's Export Council's Subcommittee on Technology and Competitiveness.
In 2008 James became a regular donor and fundraiser host for Barack Obama. In May 2012, James, a Democrat, hosted a fundraiser at his home in New York for President Barack Obama, raised more than $2 million for the President's reelection campaign. Obama offered James the job of Commerce Secretary but he ultimately turned it down.