In 2004, Ramis turned down the opportunity to direct the Bernie Mac-Ashton Kutcher film Guess Who, then under the working title "The Dinner Party," because he considered it poorly written. That same year, he began filming the low-budget The Ice Harvest, "his first attempt to make a comic film noir." Ramis spent six weeks trying to get the film greenlit because he had difficulty reaching an agreement about stars John Cusack's and Billy Bob Thornton's salaries. The film received mixed reviews. In 2004, Ramis's typical directing fee was $5 million.
In 2004, Ramis was inducted into the St. Louis Walk of Fame. In 2005, he received the Austin Film Festival's Distinguished Screenwriter Award. In 2010, he received a lifetime achievement award from the Chicago Improv Festival. In 2015, the Writers Guild of America posthumously honored him with their lifetime achievement award, the Laurel Award for Screenwriting Achievement.