After graduating from Columbiana High School, Firestone worked for the Columbus Buggy Company in Columbus, Ohio before starting his own company in 1890, making rubber tires for carriages. In 1900 he soon saw the huge potential for marketing tires for automobiles and then founded the Firestone Tire and Rubber Company, a pioneer in the mass production of tires. In 1926 he published a book, Men and Rubber: The Story of Business, which was written in collaboration with Samuel Crowther.

On November 20, 1895, Firestone married Idabelle Smith. They eventually had seven children. Notable great-grandchildren include: Andrew Firestone, Nick Firestone, and William Clay Ford Jr. (the son of Henry Ford’s grandson and Harvey and Idabelle’s granddaughter Martha).

The main library of Princeton University is named Firestone Library in his honor. It is among the largest university libraries in the world. On August 3, 1950, the Harvey S Firestone Memorial, a large sculpture ensemble dedicated to Firestone, created by sculptors James Earle Fraser and Donald De Lue was dedicated. It is located at Bridgestone Firestone Inc., 1200 Firestone Parkway in Akron, Ohio. In 1974, Firestone was inducted into the Automotive Hall of Fame. Firestone High School in Akron, Ohio, is named in his honor. There is a Harvey S Firestone Park in Columbiana, Ohio. The town Harbel in Liberia, home to Firestone’s rubber plantation, the largest in the world, is named after Firestone and his wife Idabelle.

Firestone was born on the Columbiana, Ohio farm built by his paternal grandfather. He was the second of Benjamin and Catherine (née Flickinger) Firestone’s three sons; Benjamin had a son and a daughter by his first wife. In 1983 the original farm was disassembled and moved to Greenfield Village, an 90-acre (360,000 m) historical site founded by Henry Ford, and is now part of a larger outdoor museum.

He was inducted into the Motorsports Hall of Fame of America in 2013.