On 15 February 2013, at the West End's Gielgud Theatre she began a turn as Elizabeth II in the World Premiere of Peter Morgan's The Audience. The show was directed by Stephen Daldry. In April she was named best actress at the Olivier Awards for her role.
The following year, Mirren replaced Bette Midler in David Mamet's biographical television film Phil Spector about the American musician. The HBO film focuses on the relationship between Spector and his defense attorney Linda Kenney Baden, played by Mirren, during the first of his two murder trials for the 2003 death of Lana Clarkson in his California mansion. Spector received largely mixed to positive reviews from critics, particularly for Mirren and co-star Al Pacino's performances, and was nominated for eleven Primetime Emmy Awards, also winning Mirren a Screen Actors Guild Award at the 20th awards ceremony. The film drew criticism both from Clarkson's family and friends, who charged that the suicide defense was given more merit than it deserved, and from Spector's wife, who argued that Spector was portrayed as a "foul-mouthed megalomaniac" and a "minotaur". Also in 2013, Mirren voiced the character of Dean Abigail Hardscrabble in Pixar's computer-animated comedy film Monsters University, which grossed $743 million against its estimated budget of $200 million, and reprised her role in the sequel film Red 2. The action comedy received a mixed reviews from film critics, who called it a "lackadaisical sequel", but became another commercial success, making over $140 million worldwide.
In 2013, Mirren was announced as one of several new models for Marks & Spencer's "Womanism" campaign. Subtitled "Britain's leading ladies", the campaign saw Mirren appear alongside British women from various fields, including pop singer Ellie Goulding, double Olympic gold medal-winning boxer Nicola Adams, and writer Monica Ali. In March 2013, The Guardian listed Mirren as one of the 50 best-dressed over 50.