Nomo had become one of the most popular baseball players in Japan but after the 1994 season, Nomo got into a contract dispute with team management. The Buffaloes rebuffed Nomo's demands to have a contract agent and multi-year contract. Because he was drafted by Kintetsu, the Buffaloes retained exclusive rights to Nomo; however, Nomo's agent, Don Nomura, found a loophole in the Japanese Uniform Players Contract to enable him to become a free agent. The "voluntary retirement clause" allowed a player who retired to play for whomever he wished after returning to active status. This led to him heading to the U.S., where in February 1995, the Los Angeles Dodgers signed him.
Nomo made his U.S. pro baseball debut with the Bakersfield Blaze on April 27, 1995, against the Rancho Cucamonga Quakes. Placed on a 90-pitch limit, and throwing mainly fastballs, Nomo pitched 5⅓ innings, taking the 2–1 loss against the Quakes. On May 2, after a month in the minors necessitated by a player's strike, he became the first Japanese-born Major Leaguer to appear in a major league game since Masanori Murakami in 1965. He was also the first Japanese-born player to relocate permanently to the American major leagues, as Murakami played only two seasons with the San Francisco Giants and then returned to the Japanese major leagues for the remainder of his career. The pressure on Nomo would be tremendous, and Japanese media and fans appeared in large numbers in games he started. Nomo's games were regularly broadcast live to Japan, despite the fact most people would be waking up when he started games.
The tornado delivery that baffled batters in Japan had the same effect on major league hitters, and he led the league in strikeouts in 1995 (while finishing second in walks) and was second with a 2.54 ERA. He struck out 11.101 batters per 9 innings to break Sandy Koufax's single-season franchise record of 10.546 in 1962. He also started that year's All-Star Game, striking out three of the six batters he faced. He topped out at 93 mph in that game. But he only barely won NL Rookie of the Year honors that year over future MVP Chipper Jones, as many voters felt that his Japanese success made him anything but a rookie, although he qualified by Major League rules. Nomo had another fine season in 1996 which was capped by a no-hitter thrown on September 17 in the unlikeliest of places, Denver's Coors Field, a park notoriously known as being a hitters' park because of its high elevation, semi-arid climate, and lack of foul territory. Nomo's no-hitter remains as the only one in Coors Field, and was the last Dodger to throw a no-hitter until Josh Beckett completed one on May 25, 2014.