Chester Arthur Burnett was born on June 10, 1910, in White Station, Mississippi to Gertrude Jones and Leon “Dock” Burnett. He would later say that his father was “Ethiopian”, while Jones had Choctaw ancestry on her father’s side. He was named for Chester A. Arthur, the 21st President of the United States. His physique garnered him the nicknames “Big Foot Chester” and “Bull Cow” as a young man: he was 6 feet 3 inches (191 cm) tall and often weighed close to 300 pounds (136 kg).

In 1930, Burnett met Charley Patton, the most popular bluesman in the Mississippi Delta at the time. He would listen to Patton play nightly from outside a nearby juke joint. There he remembered Patton playing “Pony Blues”, “High Water Everywhere”, “A Spoonful Blues”, and “Banty Rooster Blues”. The two became acquainted, and soon Patton was teaching him guitar. Burnett recalled that “the first piece I ever played in my life was … a tune about hook up my pony and saddle up my black mare”—Patton’s “Pony Blues”. He also learned about showmanship from Patton: “When he played his guitar, he would turn it over backwards and forwards, and throw it around over his shoulders, between his legs, throw it up in the sky”. Burnett would perform the guitar tricks he learned from Patton for the rest of his life. He played with Patton often in small Delta communities.

Burnett was influenced by other popular blues performers of the time, including the Mississippi Sheiks, Blind Lemon Jefferson, Ma Rainey, Lonnie Johnson, Tampa Red, Blind Blake, and Tommy Johnson. Two of the earliest songs he mastered were Jefferson’s “Match Box Blues” and Leroy Carr’s “How Long, How Long Blues”. The country singer Jimmie Rodgers was also an influence. Burnett tried to emulate Rodgers’s “blue yodel” but found that his efforts sounded more like a growl or a howl: “I couldn’t do no yodelin’, so I turned to howlin’. And it’s done me just fine”. His harmonica playing was modeled after that of Sonny Boy Williamson II, who taught him how to play when Burnett moved to Parkin, Arkansas, in 1933.

On April 9, 1941, he was inducted into the U.S. Army and was stationed at several bases around the country. He found it difficult to adjust to military life, and was discharged at the end of his hitch in November 3, 1943. He returned to his family, which had recently moved near West Memphis, Arkansas, and helped with the farming while also performing, as he had done in the 1930s, with Floyd Jones and others. In 1948 he formed a band, which included the guitarists Willie Johnson and Matt “Guitar” Murphy, the harmonica player Junior Parker, a pianist remembered only as “Destruction” and the drummer Willie Steele. Radio station KWEM in West Memphis began broadcasting his live performances, and he occasionally sat in with Williamson on KFFA in Helena, Arkansas.

Howlin’ Wolf had a series of hits with songs written by Willie Dixon, who had been hired by the Chess brothers in 1950 as a songwriter, and during that period the competition between Muddy Waters and Howlin’ Wolf was intense. Dixon reported “Every once in a while Wolf would mention the fact that, ‘Hey man, you wrote that song for Muddy. How come you won’t write me one like that?’ But when you’d write for him he wouldn’t like it.” So, Dixon decided to use reverse psychology on him, by introducing the songs to Wolf as written for Muddy, thus inducing Wolf to accept them.

In 1951, Ike Turner, who was a freelance talent scout, heard Howlin’ Wolf in West Memphis. Turner brought him to record several songs for Sam Phillips at Memphis Recording Service (later renamed Sun Studio) and the Bihari brothers at Modern Records. Phillips praised his singing, saying, “God, what it would be worth on film to see the fervour in that man’s face when he sang. His eyes would light up, you’d see the veins come out on his neck and, buddy, there was nothing on his mind but that song. He sang with his damn soul.” Howlin’ Wolf quickly became a local celebrity and began working with a band that included the guitarists Willie Johnson and Pat Hare. Sun Records had not yet been formed, so Phillips licensed his recording to Chess Records. Howlin’ Wolf’s first singles were issued by two different record companies in 1951: “Moanin’ at Midnight”/”How Many More Years” released on Chess, “Riding in the Moonlight”/”Morning at Midnight,” and “Passing By Blues”/”Crying at Daybreak” released on Modern’s subsidiary RPM Records. In December 1951, Leonard Chess was able to secure Howlin’ Wolf’s contract, and at the urging of Chess, he relocated to Chicago in late 1952.

In the 1950s, Howlin’ Wolf had five songs on the Billboard national R&B charts: “Moanin’ at Midnight”, “How Many More Years”, “Who Will Be Next”, “Smokestack Lightning”, and “I Asked for Water (She Gave Me Gasoline)”. His first LP, Moanin’ in the Moonlight, was released in 1959. As was standard practice in that era, it was a collection of previously released singles.

In the early 1960s, Howlin’ Wolf recorded several songs that became his most famous, despite receiving no radio play: “Wang Dang Doodle”, “Back Door Man”, “Spoonful”, “The Red Rooster” (later known as “Little Red Rooster”), “I Ain’t Superstitious”, “Goin’ Down Slow”, and “Killing Floor”, many of which were written by Willie Dixon. Several became part of the repertoires of British and American rock groups, who further popularized them. Howlin’ Wolf’s second compilation album, Howlin’ Wolf (often called “the rocking chair album”, from its cover illustration), was released in 1962.

During the blues revival in the 1950s and 1960s, black blues musicians found a new audience among white youths, and Howlin’ Wolf was among the first to capitalize on it. He toured Europe in 1964 as part of the American Folk Blues Festival, produced by the German promoters Horst Lippmann and Fritz Rau. In 1965, he appeared on the popular television program Shindig! at the insistence of the Rolling Stones, whose recording of “Little Red Rooster” had reached number one in the UK in 1964. In the late 1960s and early 1970s, Howlin’ Wolf recorded albums with others, including The Super Super Blues Band, with Bo Diddley and Muddy Waters; The Howlin’ Wolf Album, with psychedelic rock and free-jazz musicians like Gene Barge, Pete Cosey, Roland Faulkner, Morris Jennings, Louis Satterfield, Charles Stepney and Phil Upchurch; and The London Howlin’ Wolf Sessions, accompanied by the British rock musicians Eric Clapton, Steve Winwood, Ian Stewart, Bill Wyman, Charlie Watts and others.

Burnett’s health began declining in the late 1960s. He had several heart attacks and suffered bruised kidneys in a car accident in 1970. Concerned for his health, the bandleader Eddie Shaw limited him to performing 21 songs per concert.

In 1972, Howlin’ Wolf was awarded an honorary doctor of arts degree from Columbia College in Chicago.

A Howlin’ Wolf recording of “Smokestack Lightning” was selected for a Grammy Hall of Fame Award, an award established in 1973 to honor recordings that are at least 25 years old and have “qualitative or historical significance”.

In January 1976, Burnett checked into the Veterans Administration Hospital in Hines, Illinois, for kidney surgery. He died of complications from the procedure on January 10, 1976, at the age of 65. He was buried in Oakridge Cemetery, outside Chicago, in a plot in Section 18, on the east side of the road. His gravestone has an image of a guitar and harmonica etched into it.

On September 17, 1994, the U,S. Postal Service issued a 29-cent commemorative postage stamp depicting Howlin’ Wolf.

On June 25, 2019, The New York Times Magazine listed Howlin’ Wolf among hundreds of artists whose material was reportedly destroyed in the 2008 Universal fire.