On March 5, 2015, Pence suffered a fractured left forearm after being hit by a pitch during a spring training game against the Chicago Cubs. He started the regular season on the disabled list, ending his league-leading iron man streak of consecutive games played at 383. Pence started a rehab assignment with the Triple-A Sacramento River Cats on May 8 and was activated from the disabled list on May 16. Pence batted .282 with two home runs and 13 RBIs in 18 games before returning to the disabled list on June 11 with left wrist tendinitis.
On December 3, 2015, Pence announced his engagement to Alexis Cozombolidis, to whom he proposed at Walt Disney World. They married on November 26, 2016.
Pence is the San Francisco host for Big League Impact, an eight-city fantasy football network created and led by longtime St. Louis Cardinals pitcher Adam Wainwright. In 2015, the organization raised more than $1 million for various charitable organizations.