Hjejle also appeared in the 1996 film Portland, Mifune’s Last Song in 1999, The Emperor’s New Clothes in 2002, and in Dreaming of Julia and Flickering Lights in 2003. For her performance in Mifune’s Last Song, she won an Honourable Mention at the 49th Berlin International Film Festival. It was also at the same festival that she was discovered by Stephen Frears, who offered her a part in his film High Fidelity (2000), where she played John Cusack’s character’s girlfriend Laura. In 2008 he offered her a part in Chéri, in a cameo as Marie Laure. Her involvement was a part of a minor international comeback. Additionally, the same year she worked on Defiance with Daniel Craig and in 2009 she filmed The Eclipse, which received a limited theatrical release in 2010.

Hjejle was born in Copenhagen. She has starred in a series of Danish movies, including a Dogme 95 movie, and also in Danish-produced action films such as Old Men in New Cars. She also played the Swedish Queen Sofia Magdalena in SVT’s successful period drama production of The Marriage of Gustav III in 2001.

Iben Hjejle was a part of the Danish popular television series Anna Pihl until its ending in April 2008, after three seasons. In 2012, she was cast as the lead in the crime-show Dicte The show debuted in early 2013, while reviews were mixed, Hjejle received good reviews for her performance.