He is the Principal of the Quantum Pacific Group, a Guernsey-based holding corporation. He is also the majority shareholder of Pacific Drilling, a public company listed on the New York Stock Exchange, and the Israel Corporation, the largest public holding listed on the Tel Aviv Stock Exchange. He served as the Chairman of the Israel Corporation from 1999 to 2010, and as a member of its board of directors from 1999 to 2013. He has served on the Advisory Boards of Synergy Ventures and Aspect Enterprise Solutions. He was an investor in Better Place, an electric car company which went bankrupt in May 2013.
In 2013, he donated £25 million to his alma mater the London Business School through the Idan and Batia Ofer Foundation. As a result of the charitable gift, the largest private donation the school has ever received, the LBS built the Sammy Ofer Centre in 2017 in honor of his father.
In 2013, he made a donation to the John F. Kennedy School of Government at Harvard University for the establishment of the Sammy Ofer Graduate Fellowship Fund for Emerging Leaders from Israel and Palestine, a scholarship program for Israeli and Palestinian students to attend the school. It offers full tuition every year to four Israeli or Palestinian students who have demonstrated their commitment to fostering peace in the region.