Tall at 180 cm (5’11”) and with a weight of 50 kg (110 lb), she began her career as a model in 1974 at the age of 17. She quickly became nicknamed by many as “the talking mannequin”, due to her tendency to talk with fashion journalists and express her opinions on her profession and on fashion.

In 1975, at the age of 18, La Fressange appeared for the first time in photos by Oliviero Toscani for Elle magazine, then modelled for Thierry Mugler and other designers.

In 1983 she became the first model to sign an exclusive modeling contract with the haute couture fashion house, Chanel, by fashion designer Karl Lagerfeld, whose muse she became due to her remarkable resemblance to the brand’s founder, Coco Chanel, who died in 1971. She was the first model to sign an exclusivity contract with a fashion house and the first model to become a big media personality and popular figure in fashion history, a symbol of the 1980s due to her omnipresence.

However, in 1989, Lagerfeld and La Fressange had an argument and parted company. Likely this argument was, at least in part, regarding her decision to lend her likeness to a bust of Marianne, the ubiquitous symbol of the French Republic. Lagerfeld reputedly condemned her decision, saying that Marianne was the embodiment of “everything that is boring, bourgeois, and provincial” and that he would not dress up historic monuments.

On 9 June 1990, in Tarascon, France, she married nobleman Luigi d’Urso (1951-2006), who was an Italian railroad executive and died in 2006. Luigi was the son of Don Alessandro d’Urso, and his wife, Donna Clothilde Serra dei Duchi di Cassano, daughter of Don Luigi Serra, 9th Duke di Cassano, and Elizabeth Grant; and great-granddaughter of George Clymer, one of the Founding Fathers of the United States, who signed both the United States Declaration of Independence in 1776 and the United States Constitution in 1787). Luigi and Inès had two daughters, Nine Marie d’Urso (born 27 February 1994) and Violette Marie d’Urso (born 6 August 1999). She also has two stepdaughters, Clotilde d’Urso and India d’Urso, the daughters of Luigi d’Urso by his first wife, Guendalina Levier.

In 1991, with the financial support of the luxury brand, Orcofi, she created her own brand ‘Inès de la Fressange’ and opened her own Boutique, selling various products such as perfumes originating from the area in which her grandfather lived, at 12 Avenue Montaigne in the 8th arrondissement of Paris. It was an immediate success not only in France, but also in the USA and in Japan.

In December 1999, due to equity dilution, she was made redundant from her own company in which she was not a majority shareholder, her majority co-shareholders insisting it was because she had designed a pill-dispenser for the ‘Elixir of Abbé Soury’. She lost the rights to use her name and personal brand, which she fought five years for in court.