Born in Kingfisher Creek in Indian Territory (now the state of Oklahoma), Hoxie was the son of a veterinarian father, Bart “Doc” Hoxie, who was killed in a horse accident just weeks before Jack’s birth, and a half–Nez Perce mother (some reports list her as Cherokee), Matilda E. Hoxie (née Quick). After his father’s death he and his mother moved to Northern Idaho where, at an early age, Jack became a working cowboy and ranch hand. Matilda married a rancher and horse trader named Calvin Scott Stone. The family then relocated to Boise, where Jack worked as a packer for a US Army fort in the area, continuing to hone his skill as a horseback rider while competing in rodeos. In 1905, aged 20, he married Pearl Gage. The marriage lasted only a few months before the couple divorced.

In 1909 he met performer Dick Stanley and joined his Wild West show. He performed as bronco rider in the show. It was during this period that Jack met and married his first wife, Hazel Panting, who was a Western trick rider with the outfit.

Hoxie continued to tour with circuit rodeos until 1913, when he was approached to perform in the Western drama film short The Tragedy of Big Eagle Mine. Now billing himself as Hart Hoxie (a moniker he would use until 1919), he would continue working through the 1910s in popular Western shorts, often in small but well-received roles. In 1919, after appearing in approximately 35 films, he was cast in the starring role in the Paul Hurst-directed Lightning Bryce serials as main character Sky Bryce. Hoxie began billing himself as Jack Hoxie and used this name thereafter. It was during this time that he met and married his second wife, actress and frequent co-star Marin Sais, after his divorce from Hazel Panting. Although he rarely strayed from the Western film genre, several notable exceptions include his role as Perrone in the 1916 historical drama The Dumb Girl of Portici, starring Anna Pavlova; a role in the 1916 epic drama film Joan the Woman. starring Geraldine Farrar; and his role as Sandusky in the 1917 drama Nan of Music Mountain, starring Wallace Reid and Ann Little.

Through the early 1920s Hoxie became an extremely popular western film star and worked for such film companies as Pathé Exchange, Arrow Film Corporation, National Film Corp. and Sunset Pictures. In 1923 Universal Pictures head Carl Laemmle put Hoxie under contract and soon his career was on par with that of other Western stars of the era: Art Acord, Harry Carey and Hoot Gibson. Hoxie appeared in such high-profile films as 1923’s Where Is This West? with newcomer Mary Philbin and 1924’s Universal promotional film Hello, ‘Frisco, alongside such popular actors of the era as Jackie Coogan, Norman Kerry, Barbara La Marr, Antonio Moreno, Anna Q. Nilsson, Bebe Daniels and Rin Tin Tin. The film was designed to showcase Universal’s roster of its most popular actors. Hoxie, often atop his horses Fender and Dynamite, would star alongside such actresses as Marceline Day, Alice Day, Helen Holmes, Louise Lovely, Lottie Pickford and Fay Wray in westerns throughout the silent era.

In 1926 Laemmle and Universal chose Jack to star as Buffalo Bill Cody in Metropolitan Pictures’ The Last Frontier, co-starring William Boyd. The film would prove enormously successful. In 1927, however, Hoxie became dissatisfied with his contract at Universal and refused to renegotiate for another stint at the studio. He would continue throughout the late 1920s making films with lower-rank film studios. He made his last silent film, Forbidden Trail, in 1929 before pursuing further work in circuit rodeos, carnivals and the Miller Brothers 101 Ranch Wild West Show.

Hoxie eventually divorced and married his third wife, Dixie Starr. The couple briefly operated the Broken Arrow Ranch, a dude ranch in Hereford, Arizona. After a fire consumed the ranch, Hoxie returned to Wild West shows, often billed as the “Famous Western Screen Star”. Hoxie performed throughout the 1940s and well into the 1950s before finally making his last public appearance as a performer in 1959 for the Bill Tatum Circus.

Hoxie divorced Starr and married his fourth wife, Bonnie Avis Showalter, and the couple retired to a small ranch in Arkansas, then later moved to his mother Matilda’s old homestead in Oklahoma. In his later years Hoxie developed leukemia, and he died in 1965 at the age of 80. He was interred at the Willowbar Cemetery in Keyes, Oklahoma with the epitaph “A Star in Life – A Star in Heaven”.