Quaid was born on April 24, 1992 in Los Angeles, California. He is one of two children of actress Meg Ryan and the first of three children for Dennis Quaid. He attended NYU’s Tisch School of the Arts for three years.

In 2012, Quaid made his film debut as Marvel in the film The Hunger Games. In an interview, Quaid explained how he auditioned for the role: “We had torrential downpours, flooding, scorching heat and then a bear would wander onto the set. But it was an amazing bonding experience. We definitely all had a great story to tell about what we did on our summer vacation.” He also said that he was warned of a backlash from fans because of his character’s dastardly acts: “When I got cast, I was told that people would be spitting on me in the streets.” In 2013, Quaid reprised Marvel for a flashback scene in The Hunger Games: Catching Fire in a cameo appearance.

Quaid appeared in the main cast of the short-lived HBO television series Vinyl, which premiered in February 2016. In 2017, he appeared in Steven Soderbergh’s heist comedy Logan Lucky, and starred as Jordan Welch in the horror comedy film Tragedy Girls, which was released in theaters on October 20, 2017.

On March 6, 2018, Deadline announced that Quaid was cast as Hugh “Hughie” Campbell, the lead role of the Amazon drama series The Boys. The series premiered on July 2019. Since its debut, it has been renewed for a second and third season.

In July 2019, Variety announced that Quaid was cast as Ensign Brad Boimler in the new CBS All Access animated series Star Trek: Lower Decks. This follows his voice acting role on the Netflix animated series Harvey Girls Forever! In September 2020, Quaid was cast in an undisclosed role on the fifth Scream film, which will be released on January 14, 2022.