Rudock was named the MVP of the 2016 Citrus Bowl. Rudock became the first quarterback in Michigan history to throw for at least 250 yards in five consecutive games. Rudock completed 20-of-31 passes for 278 yards and three touchdowns, becoming just the second Michigan quarterback to throw for 3,000 yards in a single season, following John Navarre in 2003. Rudock finished his season ranked No. 2 in single-season passing yards and No. 1 in single-season completion percentage.

Rudock grew up in Weston, Florida and went to St. Thomas Aquinas High School in Fort Lauderdale, Florida, where he was the Broward County Player of the Year. In 2009, St. Thomas Aquinas went 13–1 while making it to the state semifinals. He completed 128-of-197 passes for 1,945 yards. Rudock connected with his players in the end zone for a total of thirty-four touchdowns while only turning the ball over five times. As a senior at St. Thomas Aquinas he led the team to district, regional, state and national championships with a perfect regular season. He holds records for total yards, most wins as a starting quarterback, completions, attempts, completion percentage, efficiency ratings, state titles, and national championships. He graduated in 2011.

On April 1, 2015, the Big Ten Conference approved the transfer for Rudock to enroll at the University of Michigan. He was immediately eligible for the 2015 football season. On November 14, Rudock set the Michigan record for single-game touchdown passes against Indiana, earning co-Big Ten Player of the Week with his receiver Jehu Chesson. The following week against Penn State, he became the first quarterback in school history to pass for 250 yards in three consecutive games.

The Detroit Lions selected Rudock in the sixth round of the 2016 NFL Draft. On September 3, 2016, he was waived by the Lions and was signed to their practice squad the next day. He was promoted to the Lions active roster on November 23, 2016. He spent his rookie season as the third-string quarterback behind Matthew Stafford and Dan Orlovsky, and didn’t make any game appearances. After the Lions did not re-sign Orlovsky after the 2016 season, Rudock was expected to be the backup to Stafford in 2017. The Lions drafted Miami quarterback Brad Kaaya in the 2017 NFL Draft to compete with Rudock during training camp and preseason in 2017. Rudock ultimately won the backup job after Kaaya was waived at the end of the preseason. Rudock attempted his first NFL pass in Week 13 against the Baltimore Ravens. He went 3-for-5 for twenty-four yards with one interception.

On March 14, 2018, the Lions re-signed Rudock to a one-year contract extension. He was waived on September 1, 2018 and was signed to the practice squad the next day.

On January 11, 2019, Rudock signed a reserve/future contract with the Miami Dolphins. On August 31, 2019, Rudock was released during final roster cuts and re-signed to the practice squad. He signed a reserve/future contract with the Dolphins on January 6, 2020, after his practice squad contract expired. The Dolphins waived Rudock on July 25, 2020. He was re-signed to their practice squad on September 7, 2020, and was released on September 14. He was re-signed to the practice squad again on October 3, and released again two days later.