By the time Baldwin had reached adolescence, he had discovered his passion for writing. His educators deemed him gifted, and in 1937, at the age of 13, he wrote his first article, titled “Harlem—Then and Now”, which was published in his school’s magazine, The Douglass Pilot.

While working odd jobs, Baldwin wrote short stories, essays, and book reviews, some of them later collected in the volume Notes of a Native Son (1955). He befriended actor Marlon Brando in 1944 and the two were roommates for a time. They remained friends for over twenty years.

Baldwin’s first published work, a review of the writer Maxim Gorky appeared in The Nation in 1947. He continued to publish in that magazine at various times in his career and was serving on its editorial board at his death in 1987.

During his teenage years, Baldwin began to realize that he was gay. In 1948 New Jersey, he walked into a restaurant where he knew he would be denied service. When the waitress explained that black people were not served there, Baldwin threw a glass of water at her which shattered against the mirror behind the bar.

Later support came from Richard Wright, whom Baldwin called “the greatest black writer in the world.” Wright and Baldwin became friends, and Wright helped Baldwin secure the Eugene F. Saxon Memorial Award. Baldwin’s essay “Notes of a Native Son” and his collection Notes of a Native Son allude to Wright’s novel Native Son. In Baldwin’s 1949 essay “Everybody’s Protest Novel”, however, he indicated that Native Son, like Harriet Beecher Stowe’s Uncle Tom’s Cabin, lacked credible characters and psychological complexity, and the friendship between the two authors ended. Interviewed by Julius Lester, however, Baldwin explained “I knew Richard and I loved him. I was not attacking him; I was trying to clarify something for myself.” In 1965, Baldwin participated in a debate with William F. Buckley, on the topic of whether the American dream had been achieved at the expense of African Americans. The debate took place at The Cambridge Union in the UK. The spectating student body voted overwhelmingly in Baldwin’s favour.

In 1949 Baldwin met and fell in love with Lucien Happersberger, a boy aged 17, though Happersberger’s marriage three years later left Baldwin distraught. When the marriage ended they later reconciled, with Happersberger staying by Baldwin’s deathbed at their house in Saint-Paul-de-Vence. Happersberger died on August 21, 2010 in Switzerland.

In 1953, Baldwin’s first novel, Go Tell It on the Mountain, a semi-autobiographical bildungsroman was published. His first collection of essays, Notes of a Native Son appeared two years later. He continued to experiment with literary forms throughout his career, publishing poetry and plays as well as the fiction and essays for which he was known.

Baldwin’s second novel, Giovanni’s Room, caused great controversy when it was first published in 1956 due to its explicit homoerotic content. Baldwin again resisted labels with the publication of this work. Despite the reading public’s expectations that he would publish works dealing with African American experiences, Giovanni’s Room is predominantly about white characters.

Baldwin returned to the United States in the summer of 1957 while the civil rights legislation of that year was being debated in Congress. He had been powerfully moved by the image of a young girl, Dorothy Counts, braving a mob in an attempt to desegregate schools in Charlotte, North Carolina, and Partisan Review editor Philip Rahv had suggested he report on what was happening in the American South. Baldwin was nervous about the trip but he made it, interviewing people in Charlotte (where he met Martin Luther King Jr.), and Montgomery, Alabama. The result was two essays, one published in Harper’s magazine (“The Hard Kind of Courage”), the other in Partisan Review (“Nobody Knows My Name”). Subsequent Baldwin articles on the movement appeared in Mademoiselle, Harper’s, The New York Times Magazine, and The New Yorker, where in 1962 he published the essay that he called “Down at the Cross,” and the New Yorker called “Letter from a Region of My Mind.” Along with a shorter essay from The Progressive, the essay became The Fire Next Time.

Baldwin’s lengthy essay “Down at the Cross” (frequently called The Fire Next Time after the title of the 1963 book in which it was published) similarly showed the seething discontent of the 1960s in novel form. The essay was originally published in two oversized issues of The New Yorker and landed Baldwin on the cover of Time magazine in 1963 while he was touring the South speaking about the restive Civil Rights Movement. Around the time of publication of The Fire Next Time, Baldwin became a known spokesperson for civil rights and a celebrity noted for championing the cause of Black Americans. He frequently appeared on television and delivered speeches on college campuses. The essay talked about the uneasy relationship between Christianity and the burgeoning Black Muslim movement. After publication, several Black nationalists criticized Baldwin for his conciliatory attitude. They questioned whether his message of love and understanding would do much to change race relations in America. The book was consumed by whites looking for answers to the question: What do Black Americans really want? Baldwin’s essays never stopped articulating the anger and frustration felt by real-life Black Americans with more clarity and style than any other writer of his generation.

In 1963 he conducted a lecture tour of the South for CORE, traveling to Durham and Greensboro in North Carolina, and New Orleans. During the tour, he lectured to students, white liberals, and anyone else listening about his racial ideology, an ideological position between the “muscular approach” of Malcolm X and the nonviolent program of Martin Luther King, Jr. Baldwin expressed the hope that socialism would take root in the United States.

Baldwin also made a prominent appearance at the March on Washington for Jobs and Freedom on August 28, 1963, with Belafonte and long-time friends Sidney Poitier and Marlon Brando.

Nonetheless, he rejected the label “civil rights activist”, or that he had participated in a civil rights movement, instead agreeing with Malcolm X’s assertion that if one is a citizen, one should not have to fight for one’s civil rights. In a 1964 interview with Robert Penn Warren for the book Who Speaks for the Negro?, Baldwin rejected the idea that the civil rights movement was an outright revolution, instead calling it “a very peculiar revolution because it has to… have its aims the establishment of a union, and a… radical shift in the American mores, the American way of life… not only as it applies to the Negro obviously, but as it applies to every citizen of the country.” In a 1979 speech at UC Berkeley, he called it, instead, “the latest slave rebellion.”

Baldwin influenced the work of French painter Philippe Derome, whom he met in Paris in the early 1960s. Baldwin also knew Marlon Brando, Charlton Heston, Billy Dee Williams, Huey P. Newton, Nikki Giovanni, Jean-Paul Sartre, Jean Genet (with whom he campaigned on behalf of the Black Panther Party), Lee Strasberg, Elia Kazan, Rip Torn, Alex Haley, Miles Davis, Amiri Baraka, Martin Luther King, Jr., Dorothea Tanning, Leonor Fini, Margaret Mead, Josephine Baker, Allen Ginsberg, Chinua Achebe, and Maya Angelou. He wrote at length about his “political relationship” with Malcolm X. He collaborated with childhood friend Richard Avedon on the 1964 book Nothing Personal.

After a bomb exploded in a Birmingham church three weeks after the March on Washington, Baldwin called for a nationwide campaign of civil disobedience in response to this “terrifying crisis.” He traveled to Selma, Alabama, where SNCC had organized a voter registration drive; he watched mothers with babies and elderly men and women standing in long lines for hours, as armed deputies and state troopers stood by—or intervened to smash a reporter’s camera or use cattle prods on SNCC workers. After his day of watching, he spoke in a crowded church, blaming Washington—”the good white people on the hill.” Returning to Washington, he told a New York Post reporter the federal government could protect Negroes—it could send federal troops into the South. He blamed the Kennedys for not acting. In March 1965, Baldwin joined marchers who walked 50 miles from Selma, Alabama, to the capitol in Montgomery under the protection of federal troops.

In 1968, Baldwin signed the “Writers and Editors War Tax Protest” pledge, vowing to refuse tax payments in protest against the Vietnam War.

Baldwin settled in Saint-Paul-de-Vence in the south of France in 1970, in an old Provençal house beneath the ramparts of the famous village. His house was always open to his friends who frequently visited him while on trips to the French Riviera. American painter Beauford Delaney made Baldwin’s house in Saint-Paul-de-Vence his second home, often setting up his easel in the garden. Delaney painted several colorful portraits of Baldwin. Fred Nall Hollis also befriended Baldwin during this time. Actors Harry Belafonte and Sidney Poitier were also regular house guests.

The years Baldwin spent in Saint-Paul-de-Vence were also years of work. Sitting in front of his sturdy typewriter, his days were devoted to writing and to answering the huge amount of mail he received from all over the world. He wrote several of his last works in his house in Saint-Paul-de-Vence, including Just Above My Head in 1979 and Evidence of Things Not Seen in 1985. It was also in his Saint-Paul-de-Vence house that Baldwin wrote his famous “Open Letter to My Sister, Angela Y. Davis” in November 1970.

Maya Angelou called Baldwin her “friend and brother” and credited him for “setting the stage” for her 1969 autobiography I Know Why the Caged Bird Sings. Baldwin was made a Commandeur de la Légion d’Honneur by the French government in 1986.

In the 1986 work The Story of English, Robert MacNeil, with Robert McCrum and William Cran, mentioned James Baldwin as an influential writer of African American Literature, on the level of Booker T. Washington, and held both men up as prime examples of Black writers.

Following the death of James Baldwin in 1987, a court battle began over the ownership of his home. Baldwin had been in the process of purchasing his house from his landlady, Mlle. Jeanne Faure. At the time of his death, Baldwin did not have full ownership of the home, although it was still Mlle. Faure’s intention that the home would stay in the family. His home, nicknamed “Chez Baldwin” has been the center of scholarly work and artistic and political activism. The National Museum of African American History and Culture has an online exhibit titled “Chez Baldwin” which uses his historic French home as a lens to explore his life and legacy. Magdalena J. Zaborowska, professor of Afro-american and American studies and the John Rich Faculty Fellow at the Institute for the Humanities at the University of Michigan, Ann Arbor published a book titled Me and My House: James Baldwin’s Last Decade in France in 2018. This book uses photographs of his home and his collections to discuss themes of politics, race, queerness, and domesticity. Over the years, several efforts were initiated to save the house and convert it to an artist residency. None had the endorsement of the Baldwin estate. In February 2016, Le Monde published an opinion piece by Thomas Chatterton Williams which spurred a group of activists to come together in Paris. In June 2016 American writer and activist Shannon Cain squatted at the house for 10 days in an act of political and artistic protest. Les Amis de la Maison Baldwin, a French organization whose initial goal was to purchase the house by launching a capital campaign funded by the U.S. philanthropic sector, grew out of this effort. This campaign was unsuccessful without the support of the Baldwin Estate. Attempts to engage the French government in conservation of the property were dismissed by the mayor of Saint-Paul-de-Vence, Joseph Le Chapelain whose statement to the local press claiming “nobody’s ever heard of James Baldwin” mirrored those of Henri Chambon, the owner of the corporation that razed his home. Construction was completed in 2019 on the apartment complex that now stands where Chez Baldwin once stood.

On December 1, 1987, Baldwin died from stomach cancer in Saint-Paul-de-Vence, France. He was buried at the Ferncliff Cemetery in Hartsdale, near New York City.

In 1987, Kevin Brown, a photo-journalist from Baltimore founded the National James Baldwin Literary Society. The group organizes free public events celebrating Baldwin’s life and legacy.

In 1992, Hampshire College in Amherst, Massachusetts, established the James Baldwin Scholars program, an urban outreach initiative, in honor of Baldwin, who taught at Hampshire in the early 1980s. The JBS Program provides talented students of color from under-served communities an opportunity to develop and improve the skills necessary for college success through coursework and tutorial support for one transitional year, after which Baldwin scholars may apply for full matriculation to Hampshire or any other four-year college program.

Spike Lee’s 1996 film Get on the Bus includes a black gay character, played by Isaiah Washington, who punches a homophobic character, saying: “This is for James Baldwin and Langston Hughes.”

In 2002, scholar Molefi Kete Asante included James Baldwin on his list of 100 Greatest African Americans.

In 2005, the United States Postal Service created a first-class postage stamp dedicated to Baldwin, which featured him on the front with a short biography on the back of the peeling paper.

In 2012, Baldwin was inducted into the Legacy Walk, an outdoor public display that celebrates LGBT history and people.

Baldwin’s influence on other writers has been profound: Toni Morrison edited the Library of America’s first two volumes of Baldwin’s fiction and essays: Early Novels & Stories (1998) and Collected Essays (1998). A third volume, Later Novels (2015), was edited by Darryl Pinckney, who had delivered a talk on Baldwin in February 2013 to celebrate the fiftieth anniversary of The New York Review of Books, during which he stated: “No other black writer I’d read was as literary as Baldwin in his early essays, not even Ralph Ellison. There is something wild in the beauty of Baldwin’s sentences and the cool of his tone, something improbable, too, this meeting of Henry James, the Bible, and Harlem.”

In 2014, East 128th Street, between Fifth and Madison Avenues was named “James Baldwin Place” to celebrate the 90th anniversary of Baldwin’s birth. He lived in the neighborhood and attended P.S. 24. Readings of Baldwin’s writing were held at The National Black Theatre and a month long art exhibition featuring works by New York Live Arts and artist Maureen Kelleher. The events were attended by Council Member Inez Dickens, who led the campaign to honor Harlem native’s son; also taking part were Baldwin’s family, theatre and film notables, and members of the community.

Also in 2014, Baldwin was one of the inaugural honorees in the Rainbow Honor Walk, a walk of fame in San Francisco’s Castro neighborhood celebrating LGBTQ people who have “made significant contributions in their fields.”

Also in 2014, The Social Justice Hub at The New School’s newly opened University Center was named the Baldwin Rivera Boggs Center after activists Baldwin, Sylvia Rivera, and Grace Lee Boggs.

In 2016, Raoul Peck released his documentary film I Am Not Your Negro. It is based on James Baldwin’s unfinished manuscript, Remember This House. It is a 93-minute journey into black history that connects the past of the Civil Rights Movement to the present of Black Lives Matter. It is a film that questions black representation in Hollywood and beyond.

In 2017, Scott Timberg wrote an essay for the Los Angeles Times (“30 years after his death, James Baldwin is having a new pop culture moment”) in which he noted existing cultural references to Baldwin, 30 years after his death, and concluded: “So Baldwin is not just a writer for the ages, but a scribe whose work—as squarely as George Orwell’s—speaks directly to ours.”

In June 2019 Baldwin’s residence on the Upper West Side was given landmark designation by New York City’s Landmarks Preservation Commission.

In June 2019, Baldwin was one of the inaugural fifty American “pioneers, trailblazers, and heroes” inducted on the National LGBTQ Wall of Honor within the Stonewall National Monument (SNM) in New York City’s Stonewall Inn. The SNM is the first U.S. national monument dedicated to LGBTQ rights and history, and the wall’s unveiling was timed to take place during the 50th anniversary of the Stonewall riots.