Skoll has served as Executive Producer or Producer on nearly 100 Participant films, including Spotlight, Roma, and American Factory, and as of 2019 Participant has won 18 Oscars and received 73 Academy Award nominations. In 2020, the company received another Academy Award nomination and win for best documentary feature for American Factory.
As of 2020, Skoll has been working for over ten years to help prevent pandemics and other global threats. In 2009, Skoll donated $100 million to create the Skoll Global Threats Fund to confront threats to humanity in 5 areas: climate change, water security, pandemics, nuclear proliferation, and Middle East conflict. The Fund created and spun off a stand alone non-profit entity, Ending Pandemics, that focuses on pandemic detection and response. In 2011, Skoll's film company Participant Media co-produced the film Contagion to raise awareness about the dangers posed by pandemics. He wanted the film to be scientifically sound and encourage funding of medical experts; in 2020, media coverage noted it was "shocking in its accuracy". In 2020, Skoll donated $20 million in January, and then an additional $100 million in April, to the Skoll Foundation for use in combating the covid-19 pandemic. The $100 million donation was intended to be used to assist with covid-19 testing, contact tracing, and providing respiratory devices and other medical equipment to countries that cannot afford it or lack infrastructure to support it.