In 1951, he continued his primary (then called as ‘standard’) three in education at Osei Tutu Boarding school (Osei Tutu Senior High School) from 1951 to 1953. At Prempeh College from 1954 to 1958, he schooled from Form 1 to Form 5.

Arrived at London in 30th April, 1959 and by June was accepted into Lincoln’s Inn, London (1959–61) to study law and became qualified as a barrister in one year eight months were he was called to the bar in 1961 (London).

An Asante, Kufuor at age 23 married Theresa Kufuor (née Mensah) in 1962; they have five children together. Kufuor and his family belong to the Roman Catholic Church, and is a Senior Grand Warden of the United Grand Lodge of England Freemasons. He was born in Kumasi and started his primary and elementary school at the Kumasi Government School located in Asem built by Sir Gordon Guggisberg.

In the following year, he was called to the bar in 1962 in Ghana before he went to Oxford University for a degree course and graduated in 1964 at Exeter College, Oxford (1961–64).

In 1964, he got employed at the Ghana Commercial Bank in London as a Manager and Legal officer. His mother had asked of him to practice in Ghana hence he left London in 1965 to Ghana as the mother had already bought a first-class ticket for his return. He practiced in the Chambers of Victor Owusu with another lawyer Owusu Yaw.

From 1966 to 1969, he became the Town Clerk of Kumasi City Council [now Kumasi] at the age of 27. In the Second Republic’s Parliamentary Register Kufuor lists as his hobbies and interests table tennis, reading, football, and film shows. He was once the Chairman of Kumasi Asante Kotoko Football Club.

As Deputy Minister of Foreign Affairs he represented Ghana on a number of occasions. From 1969 to December 1971 he led Ghana’s delegation to the United Nations General Assembly in New York City, the Organization of African Unity (OAU) Ministerial Meetings in Addis Ababa, and the Summit Conference of the Non-Aligned Movement in Lusaka. In 1970 he led the Ghanaian delegation to Moscow in the Soviet Union, Prague (Czechoslovakia), and Belgrade (Yugoslavia) to discuss Ghana’s indebtedness to these countries.

As the Spokesman on Foreign Affairs and Deputy Opposition Leader of the Popular Front Party (PFP) Parliamentary Group during the Third Republic, he was invited to accompany President Limann to the OAU Summit Conference in Freetown, Sierra Leone. He was also a member of the parliamentary delegation that visited the United States in 1981 to talk to the International Monetary Fund (IMF) and the World Bank on Ghana’s economic problems.

In January 1982 the leadership of the All People’s Party (APP), which was an alliance of all the opposition parties, advised some leading members, including the Deputy Leader of the Alliance, Alhaji Iddrisu Mahama, the general secretary, Dr Obed Asamoah and Kufuor, to accept an invitation from the Provisional National Defence Council (PNDC) to serve in what was purported to be a National Government. Kufuor was appointed the Secretary for Local Government in this new government.

On 20 April 1996 Kufuor was nominated by 1034 out of 2000 delegates of the New Patriotic Party (NPP) drawn from all the 200 Constituencies of the Country to run for the President of Ghana on 10 December 1996. After campaigning for less than nine months, Kufuor polled 39.62% of the popular votes to Rawlings’ 57% in the 1996 election. On 23 October 1998 he was re-nominated by the New Patriotic Party not only to run again for President but also to officially assume the position of Leader of the Party.

Kufuor won the presidential election of December 2000; in the first round, held on 7 December, Kufuor came in first place with 48.4%, while John Atta-Mills, Jerry Rawlings’ Vice-President, came in second with 44.8%, forcing the two into a run-off vote. In the second round, held on 28 December, Kufuor was victorious, taking 56.9% of the vote. When Kufuor was sworn in on 7 January 2001, it marked the first time in Ghana’s history that an incumbent government had peacefully surrendered power to the opposition.

Kufuor was re-elected in presidential and parliamentary elections held on 7 December 2004, earning 52.45% of the popular vote in the first round and thus avoiding a run-off, while at the same time Kufuor’s party, the New Patriotic Party, was able to secure more seats in the Parliament of Ghana.

He served as Chairman of the regional grouping ECOWAS for two consecutive terms – 2003 and 2004. In 2007, due to the policy successes his administration chalked up, Kufuor had his mandate renewed in 2004 and was sworn into office on 7 January 2005. Policy direction in Kufuor’s second presidential term built on the foundations laid in the first four years. The administration pursued Ghana’s socio-economic transformation in the second term, using the three-pronged approach of private-sector development, human resource development and good governance. At the international level, Kufuor consolidated Ghana’s position as the voice of Africa, credible peace broker, beacon of democracy (Ghana was the first country to undergo Peer Review under NEPAD’s Africa Peer Review Mechanism) and responsible member of the comity of nations.

On 29 January 2007, Kufuor was elected as Chairperson of the African Union for the 2007–08 AU session. He was succeeded by Jakaya Kikwete of Tanzania on 31 January 2008. Kufuor was involved in a car accident during his presidency on 14 November 2007, in which another car collided with his, causing it to roll over several times. Kufuor was reported to be uninjured.

He renovated the Accra Sports Stadium and the Baba Yara Stadium as well as built the Essipong and Tamale stadium in 2008 to host the CAN 2008. Under Kufuor Ghana qualified for the World Cup in 2006.

In July 2009, Kufuor became a member of the SNV Netherlands Development Organisation International Advisory Board to contribute his expertise to the organisation’s poverty reduction work. In September 2009, Kufuor spoke in the Netherlands at a Dutch government event to mark ’60 years of development aid’ at the invitation of Dutch Minister Bert Koenders, which was attended by nearly 2,000 people. During his visit to the Netherlands, he was interviewed by the newspaper NRC Handelsblad and the Internationale Samenwerking magazine. He argued for the importance of effective development assistance, pointing out that development aid helped Ghana enter the international capital market.

On 21 September 2009, he delivered the prestigious Legatum Pericles Lecture at the Legatum Center for Development and Entrepreneurship at the Massachusetts Institute of Technology. Kufuor is the Governing Council Chairman of Interpeace, an international peacebuilding organisation based in Geneva since October 2009. Also in 2009, he served on the High Level Commission on the Modernization of World Bank Group Governance, which – under the leadership of Ernesto Zedillo – conducted an external review of the World Bank Group’s governance.

On 20 September 2011, Kufuor inaugurated the John Agyekum Kufuor (JAK) Foundation with a ground-breaking ceremony for the JAK Centre for Leadership, Governance and Development at the University of Ghana, Legon. The inaugural lecture, which attracted very high local and foreign dignitaries, had H.E. Horst Köhler, former president of Germany, as its guest speaker. Thabo Mbeki, former president of South Africa, and Ghana ex-president Jerry John Rawlings, Kufuor’s fiercest critic, were among the dignitaries who attended the ceremony. The ex-presidents also unveiled a plaque on 22 September 2011 for the Kufuor Presidential Library and Museum at Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, which formed part of the John A. Kufuor Foundation.

On 14 October 2011, President Kufuor received the 2011 World Food Prize, along with President Luiz Inácio Lula da Silva for his personal commitment and visionary leadership while serving as the president of Ghana, and in creating and implementing government policies to alleviate hunger and poverty in his country.

Since November 2011 Kufuor has been the first high-level Chair of the Sanitation and Water for All (SWA) partnership.

Numerous NPP supporters tried to barricade President Kufuor’s house on 7 January 2013 to prevent him from attending John Dramani Mahama’s inauguration, which the NPP as a party had decided to boycott as they felt going would undermine their challenge to Mahama’s win in court. Kufuor explained that the party had allowed him to go because he was invited as an ex-President of Ghana and not as a Member of the NPP to the chagrin of the supporters. The Ghana Police Service (GPS) reinforcement had to be sent to his abode to allow him to be able to go for the programme.

At the 62nd regular meeting which was held on 15 September 2017, the Council of the George Grant University of Mines and Technology ( UMaT) appointed Former President Kufour as the first Chancellor of the University, the appointment taking effect from 1 November 2017. The Investiture of former President Kufuor as Chancellor was held on 12 January 2018.