Known to audiences for wearing large, colorful bows in her hair, Siwa released a line of bows in 2016: JoJo's Bows, to be sold at Claire's, a fashion-accessory company aimed at 6-to-12-year-old girls. Her bows found a strong following among primary-school pupils in the United Kingdom. They were ultimately subject to bans as teachers discovered that students unable to afford the bows, which retail for approximately £8 to £12 each, were bullied by their peers. Other reasons these schools gave for the bans were distraction, harmed students' concentration, and violated the schools' dress code policies. Due to the bows' price and popularity, some stores began selling similar, homemade bows. In 2017 Siwa, whose bows are featured heavily in her music videos and general wardrobe, said they are a "symbol of power, confidence, believing-ness."
JoJo signed with Nickelodeon in 2017. She was in the film Blurt! with Jace Norman, Lip Sync Battle Shorties with Nick Cannon, and much more.