Mwegelo was born on 20 March 1987, in Washington, D.C., where her parents worked. She was raised in Dar es Salaam, Tanzania. She started primary school at Olympio Primary School, where she served as a prefect .

From a young age Mwegelo has shown leadership trait, starting as a prefect in primary school. She went on to serve as Assistant Head Girl at St. Anthony Secondary School from 2002 to 2003, during the time she was also appointed as the Secretary General for Model United Nations General Assembly in Tanzania in 2002. In high school at Loyola High School from 2004 to 2006 she served as a prefect in charge of coordinating club activities at the school from 2004 to 2005. In 2005 she was elected as Head Prefect until 2006 when she graduated high school. Mwegelo leadership career excelled during her time in university where she was engaged in various activities including being vice-president of marketing and public relations for the International Students Week in Tanzania from 2007 to 2008 and in 2009 she became the President of the International Students Week in Tanzania. She was the founder and coordinator of University of Dar Es Salaam United Nations Association Chapter in 2008. Mwegelo was the project creative coordinator of United Nations Association initiative together with UNIFEM on 16 days against violence on women and girls in 2009. She was appointed as the local ambassador for the Live Global Run water initiative in 2010. In 2011, she was appointed as Ambassador for the Walk for Water initiative that benefitted 100,000 villagers in Bagamoyo, 2011.

She attended St. Anthony Secondary School from January 2000, where she received her ordinary secondary education, graduating in 2003 with a Certificate of Secondary Education. She served as Assistant Head Girl from 2002 to 2003. In 2002, during the Model United Nations General Assembly in Tanzania she was appointed to serve as the Secretary General.

In march 2004, she joined Loyola High School in Dar Es Salaam, Tanzania to pursue her Advanced Secondary Education, graduating in February 2006 with an Advanced Certificate of Secondary Education. Mwegelo served as a prefect responsible for coordinating all club activities at the school from 2004 to 2005. She was selected as the head prefect for the school from 2005 to 2006. In April 2005, at the inter commonwealth essay competition organized by the Commonwealth of Nations she was awarded 2nd position for best essay. Nationally, she ranked 2nd among female candidates in the English language examination.

Mwegelo attended at the University of Dar Es Salaam from 2007 to 2010 where she graduated Bachelor of Arts with Honors in Political Science B.P.S. and Philosophy with a G.P.A of 4.0 . Mwegelo was the founder and coordinator of the University of Dar Es Salaam United Nations Association Chapter in 2008. With other students and partners, Mwegelo organized various initiatives including the Stand Up Campaign towards the MDGs in 2009, commemoration of the International Day of Peace with United Nations Information Centres in 2009 and the Mwalimu Nyerere Intellectual Festival (Kigoda cha Mwalimu) at the University of Dar Es Salaam in 2010. Mwegelo also served as the President of the Tanzania International Student Week in 2009.

Mwegelo was a TV presenter for the show Bongo Star Search for the 2006/2007 season which was a singing competition seeking to discover music talent from across Tanzania, she also hosted TV Shows and live events from 2006 to 2007. In 2010, Mwegelo became a regular contributor for The Citizen magazine in Tanzania for Saturday’s edition covering women and girls related issues. In 2012, she started managing Kidoti Brand and Company to which still manages up-to-date.

In October 2012, she officially launched her company goes by name Kidoti Loving Company Limited, the launch went together with introduction of her new hairline. The company did well and in December 2014, she founded Kidoti. She partnered with RainBow Shell Craft, from China. Her company produces slippers, wigs, school bags and other fashion accessories, under the Kidoti brand. Her company introduced the Be Kidotified campaign to empower students. Her firm has worked with Mohammed Dewji. In March 2017, Clouds Media Group honored her with the Malkia wa Nguvu Award in business innovation in Tanzania.In 2017 she was nominated at Africa Youth Awards for Entrepreneur Of The Year and her company Kidoti was nominated for Startup Of The Year.

Through Kidoti company, Mwegelo has organized various social and community activities. In 2015 the Kidoti inter-school Bonanza was organized and hosted by Mwegelo which was a talent and networking bonanza featuring 20 schools from Dar Es Salaam region and involved over 4000 students. In the same year, Mwegelo also organized Manjano Dream Makers mentorship program. In 2016, the ‘Be Kidotified’ campaign was launched with the aim of improving the learning environment in public schools, basketball and netball sport facilities were launched at Jangwani Girls Secondary School.

On 28 July 2018, President John Magufuli appointed her to serve as the District Commissioner of Kisarawe District and was sworn in on 3 August 2018.