Despite not initially being ordered by Netflix, the network spun-off the character's self-titled series The Punisher, released on November 17, 2017. His portrayal of the title character in season one was commended as a "truly remarkable and intense performance" for its emotional depth and "possibly the best grizzly antihero performance among all of Marvel's Netflix series to date". Bernthal likes to perform his own stunts on the show. On December 12, 2017, it was announced that the show had been renewed for season two by Netflix, which was released on January 18, 2019. A month later, the show was canceled.
In 2017, he co-starred in Sicario writer Taylor Sheridan's directorial debut Wind River, which premiered at the 2017 Sundance Film Festival. He also appeared in significant roles in Edgar Wright's Baby Driver as Griff and prison drama Shot Caller. Additionally, Bernthal starred in Irish action thriller film Pilgrimage. Set in 13th century Ireland, Bernthal plays The Mute in the film. Due to the actor's preference to stay in character on film sets, he chose not to speak to the cast or crew for the first few weeks of production. Bernthal was praised for his acting, with The Hollywood Reporter remarking that Bernthal "steals the film with his intense, nearly wordless performance... with his buff physicality and commanding presence filling the screen".
On November 17, 2017, the initial season of The Punisher and the film Sweet Virginia were both released. In Sweet Virginia, Bernthal plays Sam, a gentle motel-owner with Parkinson's disease; critics praised his performance. During the press tours at this time Bernthal's interview on Jim Norton and Sam Roberts made news due to his description of Kevin Spacey (who had faced recent sexual assault charges) of making him uncomfortable on the set of Baby Driver. Bernthal stated that he "lost all respect" for Spacey and that "[Spacey] was a bit of a bully." In the same month, Bernthal was supposed to participate in the biographical 2018 film First Man, but left the project due to his daughter's illness.