Voight was born on December 29, 1938, in Yonkers, New York, to Barbara (née Kamp) and Elmer Voight (Elemír Vojtka, Slovakia), a professional golfer. He has two brothers, Barry Voight, a former volcanologist at Pennsylvania State University, and James Wesley Voight, known as Chip Taylor, a singer-songwriter who wrote “Wild Thing” and “Angel of the Morning”. Voight’s paternal grandfather and his paternal grandmother’s parents were Slovak immigrants, while his maternal grandfather and his maternal grandmother’s parents were German immigrants. Political activist Joseph P. Kamp was his great-uncle through his mother.

Voight was raised as a Catholic and attended Archbishop Stepinac High School in White Plains, New York, where he first took an interest in acting, playing the comedic role of Count Pepi Le Loup in the school’s annual musical, The Song of Norway. Following his graduation in 1956, he enrolled at The Catholic University of America in Washington, D.C., where he majored in art and graduated with a B.A. in 1960. After graduation, Voight moved to New York City, where he pursued an acting career.

In 1962, Voight married actress Lauri Peters, whom he met when they both appeared in the original Broadway production of The Sound of Music. They divorced in 1967. He married actress Marcheline Bertrand in 1971. They separated in 1976, filed for divorce in 1978, and it was finalized in 1980. Their children, James Haven (born May 11, 1973) and Angelina Jolie (born June 4, 1975), would go on to enter the film business as actors and producers.

In the early 1960s, Voight found work in television, appearing in several episodes of Gunsmoke, between 1963 and 1968, as well as guest spots on Naked City and The Defenders, both in 1963, and Twelve O’Clock High, in 1966 and Cimarron Strip in 1968.

His theatre career took off in January 1965, playing Rodolfo in Arthur Miller’s A View from the Bridge in an Off-Broadway revival.

Voight’s film debut did not come until 1967, when he took a part in Phillip Kaufman’s crimefighter spoof, Fearless Frank. Voight also took a small role in 1967’s western, Hour of the Gun, directed by veteran helmer John Sturges. In 1968 Voight took a role in director Paul Williams’s Out of It.

In 1969, Voight was cast in the groundbreaking Midnight Cowboy, a film that would make his career. Voight played Joe Buck, a naïve male hustler from Texas, adrift in New York City. He comes under the tutelage of Dustin Hoffman’s Ratso Rizzo, a tubercular petty thief and con artist. The film explored late 1960s New York and the development of an unlikely, but poignant friendship between the two main characters. Directed by John Schlesinger and based on a novel by James Leo Herlihy, the film struck a chord with critics and audiences. Because of its controversial themes, the film was released with an X rating and would make history by being the only X-rated feature to win Best Picture at the Academy Awards. Both Voight and co-star Hoffman were nominated for Best Actor, but lost out to John Wayne in True Grit.

In 1970, Voight appeared in Mike Nichols’ adaptation of Catch-22, and re-teamed with director Paul Williams to star in The Revolutionary, as a left wing college student struggling with his conscience.

Voight played a directionless young boxer in 1973’s The All American Boy, then appeared in the 1974 film, Conrack, directed by Martin Ritt. Based on Pat Conroy’s autobiographical novel The Water Is Wide, Voight portrayed the title character, an idealistic young schoolteacher sent to teach underprivileged black children on a remote South Carolina island. The same year he appeared in The Odessa File, based on Frederick Forsyth’s thriller, as Peter Miller, a young German journalist who discovers a conspiracy to protect former Nazis still operating within Germany. This film first teamed him with the actor-director Maximilian Schell, who acted out a character named and based on the “Butcher of Riga” Eduard Roschmann, and for whom Voight would appear in 1976’s End of the Game, a psychological thriller based on a story by Swiss novelist and playwright Friedrich Dürrenmatt.

Voight was Steven Spielberg’s first choice for the role of Matt Hooper in the 1975 film Jaws, but he turned down the role, which was ultimately played by Richard Dreyfuss.

In 1978, Voight portrayed the paraplegic Vietnam veteran Luke Martin in Hal Ashby’s film Coming Home, and was awarded Best Actor at the Cannes Film Festival, for his portrait of a cynical, yet noble paraplegic, reportedly based on real-life Vietnam veteran-turned-antiwar-activist Ron Kovic, with whom Fonda’s character falls in love. The film included a much-talked-about love scene between the two. Jane Fonda won her second Best Actress award for her role, and Voight won for Best Actor in a Leading Role.

In 1979, Voight once again put on boxing gloves, starring in 1979’s remake of the 1931 Wallace Beery and Jackie Cooper vehicle, The Champ, with Voight playing the part of an alcoholic ex-heavyweight and a young Ricky Schroder playing the role of his adoring son. The film was an international success, but less popular with American audiences.

Also in 1983, Voight was slated to play Robert Harmon in John Cassavetes’ Golden Bear-winning Love Streams, having performed the role on stage in 1981. However, a few weeks before shooting began, Voight announced that he also wanted to direct the picture and was consequently dropped.

In 1985, Voight teamed up with Russian writer and director Andrei Konchalovsky to play the role of escaped con Oscar “Manny” Manheim in Runaway Train. The script was based on a story by Akira Kurosawa, and paired Voight with Eric Roberts as a fellow escapee. Voight received an Academy Award nomination for Best Actor and won the Golden Globe’s award for Best Actor. Roberts was also honored for his performance, receiving an Academy Award nomination for Best Supporting Actor.

Voight followed up this and other performances with a role in the 1986 film, Desert Bloom, and reportedly experienced a “spiritual awakening” toward the end of the decade. In 1989 Voight starred in and helped write Eternity, which dealt with a television reporter’s efforts to uncover corruption.

He made his first acting debut into television films, acting in 1991’s Chernobyl: The Final Warning, followed by The Last of his Tribe, in 1992. He followed with 1992’s The Rainbow Warrior for ABC, the story of the ill-fated Greenpeace ship sunk by French operatives in the Auckland Harbour. For the remainder of the decade, Voight would alternate between feature films and television movies, including a starring role in the 1993 miniseries Return to Lonesome Dove, a continuation of Larry McMurtry’s western saga, 1989’s Lonesome Dove. Voight played Captain Woodrow F. Call, the part played by Tommy Lee Jones in the original miniseries. Voight made a cameo appearance as himself on the Seinfeld episode “The Mom & Pop Store” airing November 17, 1994, in which George Costanza buys a car that appears to be owned by Jon Voight. Voight described the process leading up to the episode in an interview on the Red Carpet at the 2006 BAFTA Emmy Awards:

In 1992, Voight appeared in the HBO film The Last of His Tribe.

In 1995, Voight played the role of “Nate”, a fence in the film, Heat, directed by Michael Mann, and appeared in the television films Convict Cowboy, and The Tin Soldier, also directing the latter film.

In 1997, Voight appeared in six films, beginning with Rosewood, based on the 1923 destruction of the primarily black town of Rosewood, Florida, by the white residents of nearby Sumner. Voight played John Wright, a white Rosewood storeowner who follows his conscience and protects his black customers from the white rage. Voight next appeared in Anaconda. Set in the Amazon, he played Paul Sarone, a snake hunter obsessed with a fabled giant anaconda, who hijacks an unwitting National Geographic film crew who are looking for a remote Indian tribe. Voight next appeared in a supporting role in Oliver Stone’s U Turn, portraying a blind man. Voight took a supporting role in The Rainmaker, adopted from the John Grisham novel and directed by Francis Ford Coppola. He played an unscrupulous lawyer representing an insurance company, facing off with a neophyte lawyer played by Matt Damon. His last film of 1997 was Boys Will Be Boys, a family comedy directed by Dom DeLuise.

Voight played Noah in the 1999 television production Noah’s Ark, and appeared in Second String, also for TV. He also appeared with Cheryl Ladd in the feature A Dog of Flanders, a remake of a popular film set in Belgium.

Also in 2001, Voight joined Leelee Sobieski, Hank Azaria and David Schwimmer in the made-for-television film Uprising, which was based on the uprising in the Warsaw ghetto. Voight played Major-General Juergen Stroop, the German officer responsible for the destruction of the Jewish resistance, and received a Primetime Emmy Award nomination for Outstanding Supporting Actor in a Limited Series or Movie

Director Michael Mann tagged Voight for a supporting role in the 2001 biopic Ali, which starred Will Smith as the controversial former heavyweight champ, Muhammad Ali. Voight was almost unrecognizable under his make-up and toupée, as he impersonated the sports broadcaster Howard Cosell. Voight received his fourth Academy Award nomination, this time for Best Actor in a Supporting Role, for his performance.

Also in 2001, he appeared in the television mini-series Jack and the Beanstalk: The Real Story along with Vanessa Redgrave, Matthew Modine, Richard Attenborough, and Mia Sara.

In 2003, he played the role of Marion Sevillo/Mr. Sir in Holes. In 2004, Voight joined Nicolas Cage, in National Treasure as Patrick Gates, the father of Cage’s character. In 2005, he played Pope John Paul II in the second part of CBS’ miniseries, Pope John Paul II. In 2006, he was Kentucky Wildcats head coach Adolph Rupp in the Disney hit Glory Road. In 2007, he played United States Secretary of Defense John Keller in the summer blockbuster Transformers, reuniting him with Holes star Shia LaBeouf. Also in 2007, Voight reprised his role as Patrick Gates in National Treasure: Book of Secrets. He appeared in Bratz with his goddaughter Skyler Shaye.

In the CBS miniseries Pope John Paul II, released in December 2005, Voight, who was raised a Catholic, portrayed the pontiff from the time of his election until his death, garnering an Emmy nomination for the role.

In May 2008, Voight paid a solidarity visit to Israel in honor of its 60th birthday. “I’m coming to salute, encourage and strengthen the people of Israel on this joyous 60th birthday”, said Voight. “This week is about highlighting Israel as a moral beacon. At a time when its enemies threaten nuclear destruction, Israel heals.”

In 2009, Voight played Jonas Hodges, the American antagonist, in the seventh season of the hit Fox drama 24, a role that many argue is based on real life figures Alfried Krupp, Johann Rall and Erik Prince. Voight plays the chief executive officer of a fictional private military company based in northern Virginia called Starkwood, which has loose resemblances to Academi and ThyssenKrupp. Voight made his first appearance in the two-hour prequel episode 24: Redemption on November 23. He then went on to recur for 10 episodes of Season 7. He joined Dennis Haysbert as the only two actors ever to have been credited with the “Special Guest Appearance” card on 24. That same year Voight also lent his voice talents in the Thomas Nelson audio Bible production known as The Word of Promise. In this dramatized audio, Voight played the character of Abraham. The project also featured a large ensemble of other well known Hollywood actors including Jim Caviezel, Lou Gossett, Jr., John Rhys-Davies, Luke Perry, Gary Sinise, Jason Alexander, Christopher McDonald, Marisa Tomei and John Schneider.

Voight endorsed Republican presidential nominees Mitt Romney and Donald Trump in the 2012 and 2016 presidential elections respectively. Speaking at an inauguration rally for Donald Trump in January 2017 Voight said, “God answered all our prayers” by granting Trump the White House. In May 2019, Voight released a short two-part video on Twitter supporting President Trump’s policies, and calling him “the greatest president since Abraham Lincoln”.

In 2013, Voight made his much acclaimed appearance on Ray Donovan as Mickey Donovan, the main character’s conniving father. Voight received a Golden Globe Award for Best Supporting Actor – Series, Miniseries or Television Film in 2014 for his work on Ray Donovan.

On March 26, 2019, Voight was appointed to a six-year term on the Board of Trustees of the Kennedy Center in Washington DC.

In November 2020, after the United States presidential election in which the Democratic candidate Joe Biden was announced as the winner, Voight released a statement through his Twitter account, in which he stated he was “disgusted with [the] lie that Biden has been chosen, as if we all don’t know the truth.” He further implied that Biden had committed electoral fraud and proclaimed that America was engaged in “our greatest fight since the Civil War – the battle of righteousness versus Satan, because these leftists are evil, corrupt, and they want to tear down this nation.” He finished the statement by imploring his followers to fight for Trump’s reinstatement as President.