He also played in the United States, where he starred in Major League Soccer's first three seasons for the Los Angeles Galaxy and Chicago Fire. He was the first major foreign star to be signed by the league and enjoyed considerable popularity in the United States. Campos played in two back-to-back matches during a double-header event at the Rose Bowl on 16 June 1996, playing for Mexico against the United States and then the Galaxy against Tampa Bay.
Campos has appeared in commercials for the American sportswear company Nike. In 1996, wearing a black jersey (in contrast to the colorful jerseys he wore in games), Campos starred in a Nike commercial titled "Good vs Evil" in a gladiatorial game set in a Roman amphitheatre. Appearing alongside football players from around the world, including Ronaldo, Paolo Maldini, Eric Cantona, Luís Figo and Patrick Kluivert, they defend "the beautiful game" against a team of demonic warriors, before it culminates with Cantona striking the ball and destroying evil.