A. Asbjørn Jøn, an anthropologist and scholar, recognized that the series has shifted the way vampires have since been depicted in popular culture representations. Since the end of the series, Whedon has stated that his initial intention was to produce a "cult" television series and acknowledged a corresponding "rabid, almost insane fan base" that subsequently emerged. In June 2012, Slate magazine identified it as the most written about popular culture text of all time. "[M]ore than twice as many papers, essays, and books have been devoted to the vampire drama than any of our other choices—so many that we stopped counting when we hit 200".
In March 2012, Whedon stated that although television involves more compromise than film:
In August 2012, Whedon signed a deal to develop the Marvel TV show Agents of S.H.I.E.L.D. for ABC. The series focuses on the secret military law-enforcement agency featured throughout the Marvel Cinematic Universe. Created by Whedon, Jed Whedon and Maurissa Tancharoen, the show involves individuals who possess powers within the spectacle of science fiction, while also focusing on "the peripheral people ... the people on the edges of the grand adventures." The character Phil Coulson was resurrected after his death in The Avengers to helm the show.
In July 2012, at the San Diego Comic-Con International, in response to one woman who noted the anti-corporate themes in many of his films, and asked him to give his economic philosophy in 30 seconds or less, Whedon spoke out against both socialism and capitalism, saying that "ultimately all these systems don't work." He went on to say that America is "turning into Tsarist Russia."
Endorsing Barack Obama in the 2012 United States presidential election, Whedon satirically equated Mitt Romney's future as president with a zombie apocalypse, quipping, "Romney is ready to make the deep rollbacks in health care, education, social services and reproductive rights that will guarantee poverty, unemployment, overpopulation, disease, rioting—all crucial elements in creating a nightmare zombie wasteland."