Compton first made a name for herself when she was named one of the WAMPAS Baby Stars in 1926, alongside Mary Brian, Dolores Costello, Joan Crawford, Dolores del Río, Janet Gaynor and Fay Wray. Compton appeared in a long string of mostly B-movies from the 1920s through the 1950s. She was a comedy actress and protested at being stereotyped as a "dumb blonde".