In 2006, Wydra starred in a Nespresso commercial with George Clooney. In 2008, she co-starred in the comedy-drama film Be Kind Rewind, directed by Michel Gondry, and the sports drama film Sugar, directed by Anna Boden and Ryan Fleck. She then co-starred in the 2011 romantic comedy film Crazy, Stupid, Love as Jordyn. From 2011 to 2012, she appeared on the seventh and eighth seasons of the Fox medical drama series House, playing the role of Dominika Petrova, an immigrant who marries House in order to obtain a green card. Wydra then had a starring role in the 2012 fantasy thriller After, alongside Steven Strait. The following year, she had a lead role as Katya Petrovna in the science fiction film Europa Report. In March 2013, she was cast in the pilot of NBC's remake of the British drama series Bad Girls.