On 13 January 2017, Woodburn entered the Celebrity Big Brother house to participate as a housemate in its nineteenth series, entering on Day 11. After entering the house, she clashed with fellow new housemates Jessica Cunningham and Chloe Ferry after Ferry accidentally splashed her with water. She had arguments with James Jordan who mocked her for being a cleaner, as well as multiple arguments with Nicola McLean. On Day 15, Jamie O'Hara intervened in an argument between Woodburn and McLean after Kim called him a "chicken-livered bugger", Woodburn and O'Hara argued themselves and Kim told Jamie "you're an adulterer that two-timed his wife and has got three kids", this referring to Jamie cheating which was widely reported in the media. This resulted in security entering the house and Woodburn was ordered to sleep in a separate room for the night. Woodburn was immune from nominations during her first week in the house but was eventually nominated to face every eviction by her housemates. In the final, Woodburn was evicted and finished in third place with 14.52% of the final vote. Despite this, she left to a chorus of boos from the crowd, some of her former housemates could be seen jeering her on a screen behind her.
On 6 February 2017, Woodburn appeared on This Morning where she was chastised by presenter Philip Schofield over her behaviour in the house. Woodburn scolded him for not being impartial; she also criticized ex-housemate Coleen Nolan (a friend of Schofield's) and disagreed with her winning the series.