Suzuki joined the major league club on June 9, 2007, after rarely used catcher Adam Melhuse was traded to the Texas Rangers and made his debut three days later as a pinch hitter in a game against the Houston Astros.
He served as backup to veteran Jason Kendall until Kendall was traded to the Chicago Cubs on July 16, making Suzuki the Athletics everyday catcher. On July 17, 2007, pitcher Shane Komine got into a game in the eighth inning against the Texas Rangers with Suzuki doing the catching. This marked the first time in major league baseball history that there was a battery where both players were from Hawaii.
On September 10, 2007, Suzuki hit his first career grand slam in the second inning against the Seattle Mariners.
He married his wife Renee Marie Suzuki (née Vignery) in January 2007. They met at CSUF, where she was a fellow Titan who played volleyball. They have three children, a daughter born in April 2011 and sons born in November 2013 and July 2016. Suzuki took a brief paternity leave after his daughter's birth in 2011.