Jenner was born in 1997 in Los Angeles, California. The youngest daughter of 1976 Summer Olympics decathlon winner Bruce Jenner (now Caitlyn Jenner) and TV personality Kris Jenner (née Houghton), she has an older sister, Kendall. On Kris’s side of the family, she has three older half-sisters, Kourtney, Kim and Khloé Kardashian, and one older half-brother, Rob. Jenner also has three older half-brothers from Caitlyn’s side of the family—Burt, Brandon, and Brody Jenner—and an older half-sister, Casey.

In 2007, Jenner, along with her parents and siblings, Kendall, Kourtney, Kim, Khloé, and Rob, began appearing in the reality television series Keeping Up with the Kardashians, which chronicles the personal and professional lives of their family members. The series was successful for its network, E!, and has resulted in the creation of numerous spin-offs including Kourtney and Kim Take Miami, Khloé & Lamar, Kourtney and Kim Take New York, and Kourtney and Khloé Take The Hamptons, in which Jenner has made multiple guest appearances. The sisters hosted Glee: The 3D Concert Movie at the Regency Village Theater in Westwood, California in August 2011, In 2011, they were featured in Seventeen magazine’s Style Stars of the Year, and selected them as “Style Ambassadors” for the magazine. The two hosted the premiere of The Vow in Hollywood in February 2012. The Jenners also interviewed the cast of The Hunger Games premiere in the at The Nokia Theatre in Los Angeles in March 2012. Later in 2012, she starred alongside her sister Kendall and mother Kris Jenner in an episode of American reality television series America’s Next Top Model.

Jenner attended Sierra Canyon School, where she was a member of the cheerleading team. Jenner claims to have performed in plays while attending school, along with community plays. In 2012, she became homeschooled and enrolled in an at-home education program, from which she graduated with a high school diploma in July 2015 from Laurel Springs School in Ojai, California.

In 2012, Jenner and Jordyn Woods met through a mutual friend, Jaden Smith, who Kylie met in middle school and Jordyn knew since she was a child. When Smith invited the two over to hangout at his place, they immediately started hitting it off, which sparked the beginning of their friendship.

Jenner has two nail lacquers from the Nicole by OPI nail polish brand called Wear Something Spar-kylie and Rainbow in the S-kylie. Kendall and Kylie earned $100,000 each for their OPI endorsements in 2013.

On November 15, 2013, the Jenner sisters announced that they would launch The Kendall & Kylie Collection with PacSun which launched in February 2013. Since its conception, the sisters have released several collections for this line. In July 2013, the Jenner sisters launched a jewelry line with Pascal Mouawad’s Glamhouse to create the Metal Haven by Kendall & Kylie jewelry collection.

Jenner set up an eBay account where she auctions old clothing to raise money for the Children’s Hospital Los Angeles. Jenner joined her family in a charity yard sale on November 10, 2013. Proceeds from the sale were donation-matched and sent to Share Our Strength: No Kid Hungry and the Greater Los Angeles Fisher House Foundation. She joined Khloé, Kendall, Lil Twist, and The Game at PINZ bowling alley in Studio City, California for a charity bowling game on January 19, 2014. The event was held to raise money for The Robin Hood Foundation, a nonprofit for which The Game pledged to raise $1 million in donations. The Jenner sisters participated in singer Chris Brown’s two Kick’n It For Charity Celebrity Kickball games in Glendale, California on July 19, 2014 and on August 16, 2014. At the first game, she competed on actor/singer Quincy Brown’s team.

In February 2014, she and Kendall launched a shoe and handbag line for Steve Madden’s Madden Girl line. The Jenner sisters co-hosted the 2014 Much Music Video Awards, where Kylie made her acting debut in a promo for the show in Toronto, Ontario, Canada, in June 2014. In August 2014, the Jenner sisters appeared in singer PartyNextDoor’s “Recognize” music video. Jenner and her sister Kendall co-authored the dystopian science fiction novel Rebels: City of Indra: The Story of Lex and Livia, which revolved around two twin girls, Lex and Livia, in a “self-sustaining biosphere” put together from the remains of Earth known as Indra. The novel was criticized upon release as a ghostwritten work, which prompted its ghostwriter Maya Sloan to reveal that while the Jenner sisters wrote a two-page outline for what they wanted the novel to be like, Sloan was truly responsible for the writing of the book. However, the Jenners’ creative director, Elizabeth Killmond-Roman, clarified that the two had numerous Skype and FaceTime calls with Sloan to discuss the content of the novel. The novel was mostly panned by critics, and sold only 13,000 copies in its first four months on sale. The book was also given a sequel, Time of the Twins, which was also co-authored by the Jenner sisters. Jenner launched a line of hair extensions through a partnership with Bellami Hair, called Kylie Hair Kouture, in October 2014.

In August 2014, Jenner and Tyga were spotted getting close at Jenner’s 17th birthday party. Days later Tyga ended his engagement with fiancé, Blac Chyna, after dating for three years and having a two-year-old son.

Jenner became skincare brand Nip + Fab’s second-ever ambassador in March 2015.

The Jenner sisters were booed while introducing brother-in-law Kanye West’s performance at the Billboard Music Awards in May 2015. In May 2015, an episode of Keeping Up with the Kardashians premiered in which Jenner admitted to getting a lip augmentation. Her enhanced lips from lip fillers created speculation and gained her publicity. Prior to the episode’s debut, Jenner stated that she merely used lip liner and over lined her lips. As a result, the practice of suctioning one’s lips into a small glass in order to induce greater blood flow to swell the lips was called the “Kylie Jenner Challenge” (though there was no indication that Jenner herself employed this method). Jenner responded to this by stating, “I’m not here to try & encourage people/young girls to look like me or to think this is the way they should look.” In June 2015, the Jenner sisters launched their clothing line Kendall + Kylie with British fashion retailer Topshop. This Topshop clothing line also featured swimsuits. In August 2015, Jenner announced that she would be launching her first lipstick line as a part of her self-titled lip kit under the name Kylie Lip Kit. In September 2015, Jenner launched her new personalized website and mobile app. In October 2015, Jenner starred in Tyga’s music video for his song “Dope’d Up”.

In 2015, Jenner and Tyga made their relationship official when Kylie turns 18 and gets her a $320,000 Ferrari for her birthday. Jenner made an appearance in two of Tyga’s music videos, Stimulated and Dope’d Up, which confirmed the long rumored couple were finally open about their relationship.

In December 2015, Jenner made a donation of Christmas gifts to the Los Angeles LGBT Teen Center. In January 2017, Jenner donated $10,000 to her then-friend Jordyn Woods to help cover memorial costs for Woods’s father after he passed away from cancer. On her birthday in the same year, Jenner announced on her Instagram she donated $500,000 from sales of her Birthday Collection to Teen Cancer America, an organization to help hospital and outpatient facilities develop special units for teens with cancer. Jenner is an ambassador for Smile Train, a charity that funds surgery for children with cleft lips and palates. She became one of the organization’s youngest ambassadors. Jenner visited Peru with Smile Train on an episode of Life of Kylie. In 2016, Jenner launched a special-edition lip kit called “Smile,” and donated $159,500 to Smile Train to fund cleft lip and palate surgeries for 638 deserving children. In September 2019, during her appearance on The Ellen DeGeneres Show, Jenner donated $750,000 to the founder and members of a feminist organization in Florida called Nest of Love, which is dedicated to mentoring young women, helping low-income kids in the community, and promoting female empowerment.

In February 2016, Jenner’s cosmetic company was renamed to Kylie Cosmetics and the number of kits produced rose from an initial 15,000 to 500,000. Jenner released a three-minute-long promotional video for a series of lip glosses in March 2016, directed by Colin Tilley and starring fellow models Karin Jinsui, Mara Teigen, and Jasmine Sanders. The song in the video was revealed to be “Three Strikes” by Terror Jr, a band created on the same day as the release of the video; however, the lead singer, who was later revealed to be singer Lisa Vatale, was heavily speculated to be Jenner herself. However, Jenner subsequently denied any involvement with the band. In May 2016, she made her musical debut rapping on producer Burberry Perry’s song “Beautiful Day”, with Lil Yachty, model Jordyn Woods, and Justine Skye. In fall of 2016, Jenner was announced to be the new face of PUMA along with Rae Sremmurd. In April 2017, she made a surprise appearance at the Rio Americano High School prom in Sacramento alongside junior Albert Ochoa after hearing that his date had turned him down.

Jenner has been accused of appropriating African-American culture and style. In 2016, Jenner was criticized for posting a photograph of herself wearing cornrows on Instagram. In June 2017, urban streetwear brand PluggedNYC accused Jenner of stealing their designs for her collection of camouflage swimwear.

In June 2017, Jenner was placed at number 59 on the Forbes Celebrity 100, which calculates the 100 highest-paid celebrities of the previous 12 months, after earning approximately US$41,000,000, making her the youngest person on the list at 19 years old. Jenner collaborated with Melbourne-based sunglasses brand Quay Australia to release a line of sunglasses, Quay x Kylie.

Jenner starred in a reality show revolving around her life, Life of Kylie, which premiered in August 2017. On mother’s day 2018, Kylie Cosmetics launched makeup line called Kris Cosmetics, in collaboration with her mother Kris Jenner. Jenner and her half-sister Kim Kardashian launched their second collaboration KKW x Kylie Cosmetics collection on Black Friday 2018 after previously launched the first collection in 2017.

In April 2017, Jenner and Tyga broke up mainly because of their distinguishable age difference. Jenner states that their breakup didn’t end badly nor with a big fight. Rather it was the fact she was so young and she didn’t want to look back and regret how she spent her life as a young woman. The same month, Jenner and Travis Scott met at Coachella where he was performing for part of his tour. They were seen hitting it off the entire night at the event and Kylie ended up going on the rest of the tour with Travis which kicked off the start of their relationship. A month later Jenner was spotted in pictures with Travis at the Met Gala and reported to be exclusive.

In 2017, Woods appears on Jenner’s reality TV show, Life of Kylie, which showed how they maintained their friendship with their personal lives.

On June 28, 2017, the Jenner sisters announced that they would be releasing a line of vintage T-shirts for their Kendall + Kylie line of clothing called Rock vs. Rap, featuring the likenesses of various rock and rap artists including The Notorious B.I.G., Tupac Shakur, Metallica, Pink Floyd, The Doors, Ozzy Osbourne, and Led Zeppelin, with pictures of the Jenner sisters superimposed over them. The announcement of this line of products was met with swift backlash from relatives and representatives of the figures depicted on the shirts themselves, including Sharon Osbourne, Jim Jampol, and Voletta Wallace, mother of Biggie Smalls. They were also criticized on social media and were called “insensitive.” Wallace, The Doors’ manager and the estate of Jim Morrison issued a cease-and-desist letter to the Jenner sisters, writing that they did not authorize the sisters’ use of the likenesses of these musical icons. The Jenners apologized for the shirts, and pulled them from retail.

In February 2017, Australian singer Kylie Minogue won a legal battle against Jenner for name trademark “Kylie”. Jenner had filed a U.S. trademark application for use of the name “Kylie” for “advertising services” and “endorsement services” in 2015.

In January 2017, make-up artist Vlada Haggarty claimed that Jenner had stolen the creative style and aesthetic of her own work, such as the dripping gloss lip and golden finger tips, for her own products, and that Jenner had a history of taking Haggerty’s original dripping lip art and passing it off as her own. Jenner later credited Vlada on social media and her work on the creation of the logo and an undisclosed settlement was paid to avoid any future legal issues.

On February 4, 2018, Jenner and Scott broke their silence and posted on social media platforms about the birth of their daughter, Stormi, who was born on February 1. Jenner and Scott made a video for Stormi explaining their love for each other and their daughter and updates on how she was doing during her pregnancy. Scott came out with his new album, Astroworld, and Jenner appeared in his music video, Stop Trying to Be God.

In 2018, Woods appears on Jenner’s pregnancy video. In September, Kylie Cosmetics launched the Kylie x Jordyn collection which featured the best friends new eye shadow palette, highlighter palette, two lip glosses, and a lipstick.

In April 2019, Jenner and her half-sister Kim Kardashian’s KKW Beauty teamed up to launch a new fragrance. This collaboration became Jenner’s first foray into fragrance and it launched on April 26. Jenner founded her own skincare brand Kylie Skin which was launched on May 22. The brand began producing dermis products, including face washes, scrubs, moisturizers and makeup removing wipes. On June 14, 2019, Kylie Cosmetics launched their collaboration with her half-sister Khloé Kardashian called Kylie Cosmetics x Koko Kollection. This marked their third collaboration, after previously launched special collection of lip products called Koko Kollection in 2016 and the second part in 2017. In September, Jenner announced that she was serving as the makeup artistic director for Balmain’s Spring 2020 runway show at Paris Fashion Week. To celebrate the new line, Kylie Cosmetics and Balmain launched a capsule makeup collection and available on September 27, the day of the show, on the Kylie Cosmetics website. This was the first time Jenner collaborated on a makeup collection with someone outside of her family’s inner circle.

In September 2019, their relationship was put on hold when they both confirmed that they were splitting up. The reason behind their split wasn’t because they didn’t love each other anymore, but the hardest part about the relationship was having a million other people be in it, too. The two stated they still love for each other, but their focus is to raise Stormi.

In 2019, reports came out that Woods had hooked up with Tristan Thompson, Khloe’s boyfriend and father of her daughter, at a house party. The scandal put an end to Jenner and Woods friendship for good and there is no sign of communication since.

However, her appearance at Paris Fashion Week was cancelled because she was too ill to travel to Paris for work. News surfaced she received treatment for flu-like symptoms in a hospital, which later in March 2020 she revealed in response to a post by Instagram fan account she never had it but had a horrible strep and staph infection in the throat (bleeding from the mouth and all). In October 2019, Jenner filed to trademark the phrase “rise and shine,” a line that became a meme when footage of Jenner singing the phrase to her daughter, Stormi, went viral. The hashtag #RiseandShine reached one billion views on TikTok, making it the platform’s fastest-growing hashtag trend. In addition to the standard “rise and shine,” Jenner also filed to trademark “riiise and shiiinnee.” The latter trademark would cover clothing while the former would also apply to cosmetics. The next month, Jenner sold a 51 percent stake in Kylie Cosmetics to Coty, which owns other beauty brands including Covergirl, OPI, Rimmel, GHD and Clairol for $600 million.

In January 2020, Jenner announced she had trademarked Kylie Con, Kylie Kon, and Kylie Museum. In the same month, her sister Kendall confirmed that a cosmetics line in collaboration with Jenner’ Kylie Cosmetics was in the process. Kylie Cosmetics launched Kylie Cosmetics x Kendall Jenner on June 26, 2020. Still in the same month, Jenner announced that Kylie Cosmetics will launch a Valentine’s Day Collection named after Jenner’s daughter, Stormi. The Stormi Collection was launched in February 1, the same day as her daughter’s birthday. In June 2020, the Jenners sisters addressed reports that their fashion brand Kendall + Kylie has failed to pay factory workers in Bangladesh as a result of the COVID-19 pandemic. It was reported that Global Brands Group (GBG) previously listed the Kendall + Kylie brand on its website. As a result, the Jenners stated that their company is owned by a separate entity known as 3072541 Canada Inc. even though they say that their brand “has worked with CAA-GBG in the past, in a sales and business development capacity only” and that they “do not currently have any relationship at all with GBG”. In August 2020, Kylie Cosmetics launched Summer Sailor collection which marked the launch of Jenner’s first ever false lashes. In the same month, she made a cameo in Cardi B and Megan Thee Stallion’s WAP music video, alongside singers Normani and Rosalia, a petition was made asking that Jenner’s cameo be edited out of the video reached over 65,000 signatures.

In 2020, Jenner and Scott are found quarantining together during COVID-19. Jenner states that their relationship has stayed just being co-parents and that this is the best way for both of them to spend time with their daughter.

In May 2020, however, Forbes released a statement accusing Jenner of forging tax documents so she would appear as a billionaire. The publication also accused her of fabricating revenue figures for Kylie Cosmetics. The same day, Jenner responded in a series of tweets, writing: “What am I even waking up to? I thought this was a reputable site… All I see are a number of inaccurate statements and unproven assumptions lol. I’ve never asked for any title or tried to lie my way there EVER. Period”. Jenner’s attorney also demanded that Forbes retract the statements, calling the magazine’s accusations “unequivocally false”. Forbes reacted, stating that they spent months uncovering the facts and concluded that their “extensively-reported investigation was triggered by newly-filed documents that revealed glaring discrepancies between information privately supplied to journalists and information publicly supplied to shareholders”. However, Jenner became the youngest person on Forbes’s list of 100 Richest Self-Made Women in October 2020. She is the only person on the list in her 20s, and is worth $700 million.

In January 2020, Jenner gave a total of $1 million to five organisations in Australia to help tackle the bushfires. In March 2020, Jenner, her mother Kris, along with beauty company Coty donated over 6,000 pounds of hand sanitizers to Southern California hospitals to help health care workers fighting the COVID-19 pandemic. Jenner also donated $1 million to buy face masks, face shields, and other protective gear for health-care professionals who work on the front lines.