On June 29, 2010, King announced that after 25 years, he would be stepping down from his nightly job hosting Larry King Live. However, he stated that he would remain with CNN to host occasional specials. The announcement came in the wake of speculation that CNN had approached Piers Morgan, the British television personality and journalist, as King's primetime replacement, which was confirmed that September.
The final edition of Larry King Live aired on December 16, 2010, after a quarter-century. The show concluded with his last thoughts and a thank you to his audience for watching and supporting him over the years. The concluding words of Larry King on the show were, "I... I, I don't know what to say except to you, my audience, thank you. And instead of goodbye, how about so long."
On August 30, 2010, King served as the host of Chabad's 30th annual "To Life" telethon, in Los Angeles.