Kirkpatrick’s dyslexia proved to be a difficulty during some challenges, particularly when she had to read teleprompters for CoverGirl television commercials, which was one of the final contests of the season. Throughout the show, Kirkpatrick spoke fondly of her grandmother, Wanda Sue Kirkpatrick, during taped segments and often wore dresses designed by her grandmother during the judges’ comments. Wanda Sue also made a dress for Tyra Banks, which she wore on the show. Kirkpatrick was the last contestant (edited as being called second to last before Sundai Love when aired) selected for the top fourteen contestants of the petite cycle. She was the second contestant selected as a finalist over both Jennifer An and Erin Wagner and became the first contestant in ANTM history to reach the final two without ever receiving a first call-out during her time competing. Kirkpatrick ultimately lost to Nicole Fox, who was named “America’s Next Top Model” on November 18, 2009. Kirkpatrick and Fox became friends during the season and, although Kirkpatrick believed her personality was strong, she also admitted Fox’s photos were particularly strong. Kirkpatrick initially reacted emotionally to her loss and was comforted by the show’s host, retired supermodel Tyra Banks. She said of her initial reaction to the loss: “I was really devastated at the time and cried forever until my eyes swelled up and popped out of my head!” It was announced on May 12, 2011 that Kirkpatrick would join the cast again for America’s Next Top Model: All-Stars (Cycle 17) with several returning models and was placed fourth.

In 2011, she appeared in William Fitzsimmons, “Beautiful Girl” music video.

Kirkpatrick also had a cover and spread in LexScene Magazine and was featured in Steve Madden’s Summer 2010 Collection. In 2013, she was featured in British Vogue.