She appeared in Tyler Perry's Madea's Big Happy Family, which was released on April 22, 2011. She also made a cameo appearance in the premiere of VH1's Single Ladies. London joined the cast of the hit BET show The Game as a series regular from the sixth season until the series finale. She played a character named Kiera, "a former child star who starred in a Cosby Show-esque sitcom". London co-starred, alongside Paula Patton, Jill Scott, and Derek Luke, in Baggage Claim (2013), the film adaptation of playwright and director David E. Talbert's 2005 novel. In 2016, London co-starred in the film The Perfect Match as "Ginger". In 2018, London starred in the Lifetime Movies Always & 4Ever and Poinsettias for Christmas.
London dated Lil Wayne on and off. The couple's son, Kameron Carter, was born September 9, 2009. In May 2011, London said of her relationship with Wayne, "I met Wayne when I was 15 years old. I’ve known him a very long time, and we were in a relationship that didn’t make it. We tried more than once to revive it, and we were engaged briefly years ago, but we eventually parted ways. People see the 'Lil Wayne' personality and think they know who he really is. My son’s father is an intelligent, loving, and lovable person who will always be a dear friend. And that will never change. That is all." Lil Wayne's second verse on the song 'Young'n Blues", explains how he met the 15 years old, Californian, Lauren London: "young Cali sweet thang" and his relationship with her. Lil Wayne's "California Love" "now I've got an actress sticking' by my hip...shorty is reddish" is also about Lauren London, and how he proposed to her and then broke it off "and in dat box it's a ring...somebody call that thing and tell her shawty give me back my ring". In 1999–2003, Lil Wayne also had "Lauren" tattooed on his right arm, but wrote "Carter" over it, shortly before his marriage to his now ex-wife.