She chose to attend California State University, Northridge, a university with a large deaf and hard-of-hearing student population, because of its National Center on Deafness. She majored in English with an emphasis in creative writing. While in college, she joined a local deaf performing group and took up hip-hop dancing. After she graduated in May 2000, she began working at the NCOD, where she was involved in a program to improve post-secondary school education for deaf and hard-of-hearing students. Later in the year, she decided to compete in the National Association of the Deaf’s Miss Deaf America competition, have been inspired by the competition she saw two years prior. She won the preliminary competition of Miss Deaf Illinois and ultimately won Miss Deaf America. She was the second consecutive CSUN graduate to win the crown, and she was also the first competitor of either African-American or Mexican-American descent to win the pageant. Her activities in competition included an ASL performance of the book The Giving Tree by Shel Silverstein. After winning Miss Deaf America, she began a two-year stint of attending luncheons and graduation ceremonies as a spokesperson for NAD.

After graduating from CSUN, she went to Hunter College in New York to study education with the goal of becoming a children’s author. After earning her Masters Degree in Education in 2005, she started teaching kindergarten and first grade at Public School 347 in Manhattan. She was also involved with deaf community theater and film work for friends. She married Douglas Ridloff in 2006, and they had two children, both boys and both deaf. She left her teaching job to take care of the boys. The family lives in Williamsburg, Brooklyn, a neighborhood of New York.

When director Kenny Leon began producing a revival of the 1980 play Children of a Lesser God, he hired Ridloff to tutor him in American Sign Language. Leon cast Joshua Jackson as the male lead but had not cast the female lead role. By then, Ridloff had been tutoring Leon for over a year. He asked her to substitute at a read-through early on, and based on her performance, he offered her the role. The cast had an initial run at the Berkshire Theatre Group in Stockbridge, Massachusetts. One of the most challenging aspects of her role was using her voice, which she had not used since she was 13 years old. The New York Times wrote, “Ms. Ridloff compares the experience of using her voice during the play to a crotch shot, saying that at first she felt exposed, and vulnerable, and ugly.” After a year with the role and with a vocal coach, she found greater ease. She explained, “It feels empowering to me—like finally I own every part of myself, [but] I don’t see myself ever using my voice on a conversational level—that’s just not who I am.” The revival premiered on Broadway in April 2018, and The New York Times wrote, “Critics were underwhelmed by the production, but mesmerized by Ms. Ridloff.” The revival was shuttered on May 27, 2018.

Ridloff was a fan of the TV series The Walking Dead and submitted an audition tape to be cast in the series. She was cast as Connie and started her role in the show’s ninth season. In July 2019, Ridloff was cast as Makkari in the 2021 Marvel superhero film Eternals. The latter casting made her the first deaf superhero in the Marvel Cinematic Universe. To film for Eternals, Ridloff took a leave of absence from The Walking Dead, not appearing in six consecutive episodes of the show’s tenth season.