In 2005, Levine wrote, produced, and directed his debut film Territory, based on his stage play of the same name. Critic Aaron West of eFilmCritic wrote of the film, “The off-Broadway version is undoubtedly the more appropriate medium for this story, and if given a choice, I would rather see it there. Still, I cannot help but applaud Levine for trying something a little different. His characters are extraordinarily ordinary, and his tightly wound screenplay reveals their (and our) brightest and darkest sides at various times.”

In 2009, he wrote and directed the short films The Empress and Fat Friend.

Levine is married to fellow filmmaker Sophia Takal, with whom he has collaborated on several films. In 2013, Jordan Zakarin of The Hollywood Reporter named Levine and Takal two of New York’s next big independent filmmakers.

In 2014, Levine wrote, directed, and starred in the mystery/comedy Wild Canaries. The film received a positive response from critics and was praised by The Village Voice as being “…the closest a contemporary film has come to replicating the unbridled jubilance of a classic screwball comedy”. His next film, Black Bear, will star Christopher Abbott, Sarah Gadon and Aubrey Plaza.