The Athletics won the AL pennant in three successive seasons from 1929 to 1931, as well as consecutive World Series championships in 1929 and 1930. During the Athletics' championship run, Grove led the way as the league's top pitcher, posting records of 20-6, 28-5 and 31-4. In 1931, Grove led the league in wins, ERA (2.06), strikeouts (175), winning percentage, complete games, and shutouts. His 2.06 ERA was 2.32 runs below the league average. He was also chosen as league MVP in 1931, making him one of only a handful of pitchers to achieve this honor. His MVP award is the only one not enshrined in the National Baseball Hall of Fame in Cooperstown, New York, instead being housed at the George's Creek Library in Lonaconing, Maryland.
As a hitter, Grove posted a .148 batting average (202-for-1,369) with 119 runs, 15 home runs, 121 RBI and 105 bases on balls. From 1929 through 1932, Grove had 56 RBI. Defensively, he recorded a .954 fielding percentage.