Pons was born in Caracas, Venezuela. Pons moved to the United States at the age of five and was raised in Miami, Florida. She graduated from Miami Country Day School in 2015 and moved to Los Angeles, California. She has said that she had trouble making friends in high school, so she "would get hurt to make them laugh." She has also said that she was bullied at high school. She said "I'm not like the cool girls—I'm the other girl. The one that's basically a nerd, but proud of that."
Pons has used her success in Internet comedy to launch a number of enterprises. In 2015, she launched a jewelry collection called UNO Magnetic. In 2016, Pons co-authored a novel based on her own high school experiences, Surviving High School, co-authored with Melissa de la Cruz. Pons starred as Callie in the 2016 romantic comedy We Love You, released on YouTube Red. In the movie, characters played by Yousef Erakat and Justin Dobies both fall for Pons, who is "cool enough" to date both of them at the same time. The movie was produced by YouTube and AwesomenessTV.