Despite losing in the quarterfinals of the 1930 NCAA Tournament, McGuirk claimed the 155-pound title at the 1931 NCAA Tournament on March 28 in Providence. A year later, McGuirk competed in the 1932 NCAA Tournament at 174 pounds.

After graduation from college, McGuirk went to work for Sam Avey. On March 5, 1934, he beat Hugh Nichols in Tulsa for the NWA World Light Heavyweight Championship. He was also endorsed by the National Wrestling Association.

McGuirk enjoyed several runs as champion. On May 16, 1938, McGuirk beat Danny McShain to capture his second world light heavyweight title. The National Wrestling Association had a 190-pound title (later raised to 200) that was known as the World Junior Heavyweight Championship. McGuirk won this title on June 19, 1939 from John Swenski.

Between Tulsa and Hollywood, McGuirk dominated the Junior Heavyweight division, but at least three other Junior Heavyweight Champions were recognized at the time. On December 28, 1949, McGuirk unified the National Wrestling Association World Junior Heavyweight Championship with the National Wrestling Alliance’s version by defeating Billy Goelz in Des Moines.

On February 7, 1950, McGuirk’s career came to an end. In Little Rock, Arkansas, McGuirk was being driven to a restaurant by his wrestling pupil, Robert “Bob” Clay. In an attempt to prevent a collision, Clay locked the car’s brakes, and McGuirk was thrown against the front windshield. McGuirk’s tinted glasses were shattered and the side of the glasses covering his good eye were fractured, blinding McGuirk permanently. It was another Oklahoman, Danny Hodge, who rose to prominence in the Junior Heavyweight field. By 1960, Hodge became the principal headliner for McGuirk.

By 1953, McGuirk was the primary booker for the junior heavyweight champion, while coordinating talent from southwestern Missouri to Little Rock, across Oklahoma, and into parts of Texas. Despite being the booker, McGuirk also took on the opportunity to train promising wrestlers. One of his most promising was eventual NWA World Heavyweight Champion Dick Hutton. In the May 10, 1953 edition of the Tulsa Daily World, McGuirk said “He has a fine chance to get into the big money brackets. He has a lot to learn, but has the natural qualifications, and I won’t be surprised at anything he may accomplish.” Hutton did not disappoint, as he beat Lou Thesz on November 14, 1957 at Maple Leaf Gardens in Toronto.

Avey and McGuirk’s actual territory covered most of Oklahoma and Arkansas. Said territory also included Joplin and Springfield, Missouri, Shreveport, Louisiana, plus Wichita Falls, and Tyler, Texas. On January 4, 1958, McGuirk took over the entire business after Avey retired. Avey left wrestling to concentrate on his role as senior vice president of the Farmers and Merchants State Bank. One of the biggest issues McGuirk faced was the tension that occurred due to sporadic visits by world champion Buddy Rogers in the early 1960s. Many felt that the bigger promoters were locked in for visits by Rogers while territories such as McGuirk’s, Jim Crockett in Charlotte, Karl Sarpolis in Amarillo, and Cowboy Luttrall in Tampa, to name a few, were perceived as the non-essential territories.

McGuirk had many people who worked for him as matchmaker: Leo Voss, Sam Menacker, Rip Tyler, Wayne Martin, and George Scott. Of all those people, Cowboy Bill Watts played a big part in McGuirk’s promotion, both positively and negatively. His first real connection to McGuirk was in 1968, when McGuirk submitted the only vote in favor of passing the NWA Championship to him. McGuirk and Watts worked together to promote Oklahoma, Arkansas, Mississippi, and Louisiana in the late 1970s. On July 22, 1978, their joint promotion of a wrestling show at the Louisiana Superdome drew an estimated 31,000 fans and a gate of $140,000. A dispute between the two in August 1979 strained their friendship. While Watts incorporated Mid-South Sports Inc. and had agreements Jim Barnett, Eddie Graham, Fritz Von Erich, and Vincent J. McMahon that made the promotion thrive. McGuirk became desperate and hoped that George Scott would help keep the territory afloat.

McGuirk was inducted into the Oklahoma Athletic Hall of Fame in 1977. He is also a member of the Wrestling Observer Newsletter Hall of Fame. Of his charitable work, McGuirk is best known for working with Ed Lewis. They were responsible for instituting the NWA “Leader Dogs for the Blind” annual charity function.

On February 23, 1981, Watts filed documents to bring Mid-South to Tulsa. Matters worsened as seven wrestlers went on strike on August 21. Their grievance was that McGuirk had not paid them for the previous weeks work. Despite turning to Amarillo for wrestling talent, McGuirk saw the writing on the wall.

In 1982, McGuirk ceased operations and left the city open for Bill Watts and Mid-South Wrestling to take over. McGuirk’s daughter, Michael Kathleen, better known in wrestling as Mike McGuirk, married B. Brian Blair, a wrestler for Mid-South. Both eventually worked for the World Wrestling Federation: Blair as one half of the tag team The Killer Bees, and Mike McGuirk as an in-ring announcer.