Li was born in Chao’an, Chaozhou in Guangdong Province in 1928 to Teochew parents. Owing to his father’s death, he was forced to leave school before the age of 15 and found a job in a plastics trading company where he worked 16 hours a day. In 1950 he started his own company, Cheung Kong Industries. From manufacturing plastics, Li developed his company into a leading real estate investment company in Hong Kong that was listed on the Hong Kong Stock Exchange in 1972. Cheung Kong expanded by acquiring Hutchison Whampoa and Hongkong Electric Holdings Limited in 1979 and 1985 respectively.

In 1950, after learning how to operate a plant, Li founded a plastic manufacturing company in Hong Kong with personal savings and funds borrowed from relatives. Li avidly read trade publications and business news before deciding to supply the world with high quality plastic flowers at low prices. Li learned the technique of mixing colour with plastics that resemble real flowers. After retooling his shop and hiring the best technicians he could find, he prepared the plant for a visit from a large foreign buyer. Impressed with the quality of Li’s plant, the buyer placed a large order. A few years later, Li grew to be the largest supplier of plastic flowers in Asia and made a fortune selling them.

In 1958, believing rents would continue to rise, Li decided to purchase a site and develop his own factory building. An opportunity to acquire more land arrived after the 1967 riots when many people fled Hong Kong, and, as a result, property prices plummeted. Li believed the political crisis would be temporary and property prices would eventually rise, and bought land from the fleeing residents at low prices. In 1971, Li officially named his real estate development company Cheung Kong (長江實業). Cheung Kong Holdings was publicly listed in Hong Kong Stock Exchange in 1972. During board meetings, Li stated on a number of occasions his goal of surpassing the Jardines-owned Hongkong Land as a leading developer.

The successful bid by Cheung Kong for development sites above the Central and Admiralty MTR stations in 1977 was the key to challenging Hongkong Land as the premier property developer in Hong Kong. Despite its size, Jardines decided in the 1980s to protect itself from hostile takeover by Li or other outside investors. The company implemented a cross-shareholding structure that was designed to place control in the hands of Britain’s Keswick family despite their less than 10% holdings in the group. In 1984, the company also moved its legal domicile from Hong Kong to another British overseas territory – Bermuda, in anticipation of the transfer of sovereignty of Hong Kong to People’s Republic of China in 1997.

In 1979, Li purchased a major stake in Hutchison Whampoa Company Limited from Hong Kong Bank through Cheung Kong.

His son Victor Li was kidnapped in 1996 on his way home after work by gangster “Big Spender” Cheung Tze-keung. Li Ka-shing paid a ransom of HK$1 billion, directly to Cheung who had come to his house. A report was never filed with Hong Kong police. Instead the case was pursued by Mainland authorities, leading to Cheung’s execution in 1998, an outcome not possible under Hong Kong law. Rumours circulated of a deal between Li and the Mainland. In interviews, when this rumor was brought up, Li brushed it off and dismissed it completely.

CK Hutchison group has the reputation of being an astute asset trader. It builds up new businesses and sells them off when shareholder value could be created. Huge profits were obtained in the sale of its interest in Orange to Mannesmann Group in 1999, making a profit of $15.12 billion. In 2006 Li sold 20% of Hutchison’s ports business to Singapore rival PSA Corp., making a $3.12 billion profit on a $4 billion deal.

Besides business through his flagship companies CK Asset Holdings and CK Hutchison Holdings Limited, Li Ka-shing has also personally invested extensively in real estate in Singapore and Canada. He was the single largest shareholder of Canadian Imperial Bank of Commerce (CIBC), the fifth largest bank in Canada, until the sale of his share in 2005 (with all proceedings donated, see below). He is also the majority shareholder of a major energy company, Husky Energy, based in Alberta, Canada.

In January 2005, Li announced plans to sell his $1.2 billion CAD stake in the Canadian Imperial Bank of Commerce, with all proceeds going to private charitable foundations established by Li, including the Li Ka Shing Foundation in Hong Kong and the Li Ka Shing (Canada) Foundation based in Toronto, Ontario. Li was the non-executive director of The Hongkong and Shanghai Banking Corporation since 1980 and became Deputy Chairman of the bank in 1985. He was also Deputy Chairman of HSBC Holdings in 1991–1992.

In 2011, Horizons Ventures invested in Summly, a website-summarizing app. Notably, the investment made Nick D’Aloisio, Summly’s founder, the world’s youngest person to receive a venture capital investment at just fifteen years old. In 2012, Horizons Ventures invested $2.3 million in Wibbitz, a company that provides a text-to-video technology that can automatically convert any article post or feed on the web into a video in a matter of seconds. In August 2012, Li acquired a stake in Ginger Software Incorporated. In 2013, Horizons Ventures invested in Bitcoin payment company BitPay.

On 4 August 2011 at the interim results announcement for Hutchison Whampoa, Li endorsed Henry Tang for the forthcoming chief executive election. Then Li said “You all can be just like me, one-person-one-vote (一人一票).” The media then looked at Li in disbelief, and pointed out that regular citizens do not get one-person-one-vote. Li then tried to laugh it off and said “maybe in 2017 they will have one-person-one-vote to choose the chief executive, I probably just said it a little early.” Li was, however, criticised by Chinese official state-run press agency Xinhua for not being unambiguous in his opposition to the Umbrella movement protests and his support for Leung. Later, prior to the Legco vote, Li said that the largest threat to Hong Kong’s future was if the government failed to ensure passage of the 2014–5 round of political reform.

In 2013 a claim was lodged by the Australian Tax Office (ATO) against Cheung Kong Infrastructure (CKI) to pay approximately A$370 million in unpaid tax, penalties and interest relating to tax disputes concerning SA Power Networks and Victoria Power Networks. The dispute was resolved in 2015 when CKI entered into an agreement with the ATO. No penalty was levied against CKI and a sum of approximately A$24 million was refunded from the A$64 million previously paid to the ATO by CKI.

In February 2015, Horizons Ventures participated in a $30 million Series C funding round in Zoom Video Communications. Later in the year, Li participated in a $108 million Series D round in Impossible Foods. In 2016, he continued investments in technology companies and Horizons Ventures led a $55 million Series A round in Blockstream, the leader in blockchain related technologies, and also invested in a startup incubator fund Expa, that works with the founders to build new companies.

Li’s business empire has presence around the world, including China. Li came under attack from Chinese state-run tabloid paper Global Times in early 2015, when his companies put out word that it was considering selling prime Shanghai and Beijing properties. It became apparent that Li aimed at re-weighting his asset portfolio to more stable and transparent markets in the West. Concerted attacks ensued and went into a crescendo as China’s economy slowed down dramatically in the second half of the year, and the central government sought a way to stem the capital outflows. Specific reproaches were that his asset disposals were “an act of ingratitude” and “immoral at such a sensitive juncture”. Security Times, a People’s Daily publication, estimated that Li has sold at least 73.8 billion yuan worth of assets since 2014. Li’s holding companies denied divesting in China, saying that its asset disposals were being undertaken in the ordinary course of business. The attacks stopped abruptly several weeks later, when editorials in official publications such as People’s Daily, Beijing Youth Daily took a neutral stance in unison.

Li is famously plainly dressed for a Hong Kong tycoon. In the 1990s he wore a $50 HKD timepiece from Citizen Watch Co. and plain ties. He later wore a Seiko. In 2016, he wore a $500 HKD Citizen watch.

In September 2017, Li worked with Alibaba’s Jack Ma to bring AlipayHK, a digital wallet service to Hong Kong.

After his almost-70-year-long reign over CK Hutchison Holdings and CK Asset Holdings, Li announced his retirement on 16 March 2018 and the decision to pass his $100billion empire on to his son, Victor Li. He is still involved in the conglomerate as a senior advisor.