In the wake of the scandal, C.K. suffered severe repercussions, stating in 2018 that the fallout had taken him through "hell and back" and cost him approximately $35 million in lost income. The Orchard announced it would not distribute the film I Love You, Daddy, and co-stars Chloë Grace Moretz and Charlie Day said they would not participate in the film's promotion. FX Networks announced it was cutting ties with C.K., and Netflix announced that it would not be moving forward with a second planned stand-up special featuring the comedian. HBO dropped C.K.'s appearance on an upcoming Night of Too Many Stars autism television special and removed his content from their on-demand services. TBS suspended production of, and eventually scrapped, its animated series The Cops. Illumination, about to produce the animated children's film The Secret Life of Pets 2 in which C.K. was to reprise his starring role from the previous film, terminated their relationship with him and hired Patton Oswalt as his replacement. The Disney Channel also removed C.K. from reruns of Gravity Falls, redubbing his character's voice with series creator Alex Hirsch.
On August 26, 2018, C.K. made an unannounced appearance at the Comedy Cellar in Manhattan, New York. It was reported that he received an ovation from the audience, and performed a typical set making no reference to the sexual controversy.
His return to stand-up comedy was criticized by comedians including Aparna Nancherla, Ian Karmel, Allie Goertz and Judd Apatow as being premature, whereas Dave Chappelle, Chris Rock, Bill Burr, Michael Che, Jim Gaffigan, Janeane Garofalo, Sarah Silverman, Wanda Sykes, Judy Gold, Marlon Wayans, Joe Rogan, and Kurt Metzger supported C.K.'s right to continue standup. Comedian Jerry Seinfeld also supported C.K.'s return to standup but opined that the public may have felt that C.K had not owned up to his actions enough, saying in October 2018, "We know the routine: The person does something wrong. The person's humiliated. They're exiled. They suffer, we want them to suffer. We love the tumble, we love the crash and bang of the fall. And then we love the crawl-back. The grovel. Are you going to grovel? How long are you going to grovel?" Seinfeld added, "We, the court of public opinion, decided if he's going to come back, he'd better show a lot of pain. Because he denied (the public) that." Edie Falco, who starred in C.K.'s Horace and Pete and I Love You, Daddy, expressed her hope that he would receive a second chance saying: "He's someone who admitted that he did what he was accused of doing and admitted that it wasn't right" and that "people who are committed to becoming aware of what they've done and changing, they can be our strongest proponents in an issue like this."
On December 31, 2018, an audience member secretly recorded C.K. working out new material and posted it online. The comedy set included controversial topics such as Auschwitz, non-binary people and victims of the 2018 Parkland shooting. The jokes drew condemnation from Parkland survivors and a divided reaction from fellow comedians. Ricky Gervais defended C.K.'s jokes saying "[C.K.’s] got nothing against those [Parkland] kids. It was him pretending to be angry for comedy."
C.K. confirmed he was dating Blanche Gardin in 2018.