He worked as the co-director and cameraman to Jacques Cousteau on the documentary The Silent World (1956), which won an Oscar and the Palme d’Or at the 1956 Academy Awards and Cannes Film Festival respectively. He assisted Robert Bresson on A Man Escaped (French title: Un condamné à mort s’est échappé ou Le vent souffle où il veut, 1956) before making his first feature, Ascenseur pour l’échafaud in 1957 (released in the U.K. as Lift to the Scaffold and in the U.S. originally as Frantic, later as Elevator to the Gallows). A taut thriller featuring an original score by Miles Davis, Ascenseur pour l’échafaud made an international film star of Jeanne Moreau, at the time a leading stage actress of the Comédie-Française. Malle was 24 years old.

Malle visited India in 1968, and made a seven-part documentary series, L’Inde fantôme: Reflexions sur un voyage, and a documentary film, Calcutta, which was released in cinemas. Concentrating on real India, its rituals and festivities, Malle fell afoul of the Indian government, which disliked his portrayal of the country, in its fascination with the pre-modern, and consequently banned the BBC from filming in India for several years. Malle later claimed his documentary on India was his favorite film.

He married actress Candice Bergen in 1980. They had one child, a daughter, Chloé Françoise Malle, on 8 November 1985. He died from lymphoma, aged 63, at their home in Beverly Hills, California, on 23 November 1995.

Towards the end of his life, Malle was interviewed extensively for The Times by cultural correspondent Melinda Camber Porter. In 1993, the interviews were included in Camber Porter’s book Through Parisian Eyes: Reflections On Contemporary French Arts And Culture.