Born in Paris on 16 April 1755, Élisabeth Louise Vigée was the daughter of Jeanne (née Maissin) (1728–1800), a hairdresser, and portraitist and fan painter, Louis Vigée, from whom she received her first instruction. In 1760, at the age of five, she entered a convent, where she remained until 1766. Her father died when she was 12 years old. In 1768, her mother married a wealthy jeweller, Jacques-François Le Sèvre, and shortly after, the family moved to the Rue Saint-Honoré, close to the Palais Royal. In her memoir, Vigée Le Brun directly stated her feelings about her step-father: “I hated this man; even more so since he made use of my father’s personal possessions. He wore his clothes, just as they were, without altering them to fit his figure.” During this period, Élisabeth benefited from the advice of Gabriel François Doyen, Jean-Baptiste Greuze, and Joseph Vernet, whose influence is evident in her portrait of her younger brother, playwright and poet Étienne Vigée (1773).

By the time she was in her early teens, Élisabeth was painting portraits professionally. After her studio was seized for her practicing without a license, she applied to the Académie de Saint-Luc, which unwittingly exhibited her works in their Salon. In 1774, she was made a member of the Académie. On 11 January 1776 she married Jean-Baptiste-Pierre Le Brun, a painter and art dealer. Vigée Le Brun began exhibiting her work at their home in Paris, the Hôtel de Lubert, and the Salons she held here supplied her with many new and important contacts. Her husband’s great-great-uncle was Charles Le Brun, the first director of the French Academy under Louis XIV. Vigée Le Brun painted portraits of many of the nobility.

On 12 February 1780, Vigée-Le Brun gave birth to a daughter, Jeanne Lucie Louise, whom she called Julie and nicknamed “Brunette.”

In 1781 she and her husband toured Flanders and the Netherlands, where seeing the works of the Flemish masters inspired her to try new techniques. Her Self-Portrait with Straw Hat (1782) was a “free imitation” of Peter Paul Rubens’ La Chapeau de Paille (ca. 1622–1625). Dutch and Flemish influences have also been noted in The Comte d’Espagnac (1786) and Madame Perregaux (1789).

On 31 May 1783, Vigée Le Brun was received as a member of the Académie royale de peinture et de sculpture. She was one of only 15 women to be granted full membership in the Académie between 1648 and 1793. Her rival, Adélaïde Labille-Guiard, was admitted on the same day. Vigée Le Brun was initially refused on the grounds that her husband was an art dealer, but eventually the Académie was overruled by an order from Louis XVI because Marie Antoinette put considerable pressure on her husband on behalf of her portraitist. As her reception piece, Vigée Le Brun submitted an allegorical painting, Peace Bringing Back Abundance (La Paix ramenant l’Abondance), instead of a portrait. As a consequence, the Académie did not place her work within a standard category of painting—either history or portraiture. Vigée Le Brun’s membership in the Académie dissolved after the French Revolution because female academicians were abolished.

In 1787, she caused a minor public scandal when her Self-Portrait with Her Daughter Julie (1787) was exhibited at the Salon of 1787 showing her smiling and open-mouthed, which was in direct contravention of traditional painting conventions going back to antiquity. The court gossip-sheet Mémoires secrets commented: “An affectation which artists, art-lovers and persons of taste have been united in condemning, and which finds no precedent among the Ancients, is that in smiling, [Madame Vigée LeBrun] shows her teeth.” In light of this and her other Self-Portrait with Her Daughter Julie (1789), Simone de Beauvoir dismissed Vigée Le Brun as narcissistic in The Second Sex (1949): “Madame Vigée-Lebrun never wearied of putting her smiling maternity on her canvases.”

In October 1789, after the arrest of the royal family during the French Revolution, Vigée Le Brun fled France with her young daughter, Julie. Her husband, who remained in Paris, claimed that Vigée Le Brun went to Italy “to instruct and improve herself”, but she certainly feared for her own safety. In her 12-year absence from France, she lived and worked in Italy (1789–1792), Austria (1792–1795), Russia (1795–1801), and Germany (1801).

After a sustained campaign by her ex-husband and other family members to have her name removed from the list of counter-revolutionary émigrés, Vigée Le Brun was finally able to return to France in January 1802. She travelled to London in 1803, to Switzerland in 1807, and to Switzerland again in 1808. In Geneva, she was made an honorary member of the Société pour l’Avancement des Beaux-Arts. She stayed at Coppet with Madame de Staël, who appears as the title character in Corinne, ou l’Italie (1807).

Between 1835 and 1837, when Vigée Le Brun was in her 80s, she published her memoirs in three volumes (Souvenirs).

In her later years, Vigée Le Brun purchased a house in Louveciennes, Île-de-France, and divided her time between Louveciennes and Paris. She died in Paris on 30 March 1842, aged 86. She was buried at the Cimetière de Louveciennes near her old home. Her tombstone epitaph says “Ici, enfin, je repose…” (Here, at last, I rest…).

The first retrospective exhibition of Vigée Le Brun’s work was held in 1982 at the Kimbell Art Museum in Fort Worth, Texas. The first major international retrospective exhibition of her art premiered at the Galeries nationales du Grand Palais in Paris (2015—2016) and was subsequently shown at the Metropolitan Museum of Art in New York City (2016) and the National Gallery of Canada in Ottawa (2016).

The 2014 docudrama made for French television, Le fabuleux destin d’Elisabeth Vigée Le Brun, directed by Arnaud Xainte, is available in English as The Fabulous Life of Elisabeth Vigée Le Brun.