In December 2007 by the hand of Enrique Borja, Lobos signed for four years with Tigres UANL on a $3.5 million deal. Almost finishing the Clausura 2008, Lobos underwent an operation on one of his knees. On August 11, 2010, Lobos re-signed for three more years with UANL. In 2011, the post of captain was given to him for being the most committed player. On December 11, 2011, Lucas lead Tigres to their third championship, and was awarded for the second time in a row as both, the MVP and best attacking midfielder of the Mexican League. On March, 2012, Alejandro Sabella, the head coach of the Argentina national team, stated that he was considering the chance to include Lobos in the team. On November, 2012, Lobos re-signed for three more years with UANL. On June 4, 2014, it was announced that Lobos was transferred to Mexican side Toluca on a $5 million deal. After the news of the transfer of Lobos to Toluca, over a hundred fans of Tigres UANL received him at the Monterrey International Airport chanting his name on an emotional farewell. Lobos left Tigres UANL as the last idol of the team and one of the greatest players in the club's history.