Lobos and his wife Florencia are married since 2005. In 2006, his daughter Lola was born in Cadiz. On January 9, 2013, his twins, Lucia and Mateo were born in Monterrey. Lobos is fan of his former team Club de Gimnasia y Esgrima La Plata. In July 2013, Lobos became a naturalized Mexican citizen after settling in Mexico in 2008.

In December 2007 by the hand of Enrique Borja, Lobos signed for four years with Tigres UANL on a $3.5 million deal. Almost finishing the Clausura 2008, Lobos underwent an operation on one of his knees. On August 11, 2010, Lobos re-signed for three more years with UANL. In 2011, the post of captain was given to him for being the most committed player. On December 11, 2011, Lucas lead Tigres to their third championship, and was awarded for the second time in a row as both, the MVP and best attacking midfielder of the Mexican League. On March, 2012, Alejandro Sabella, the head coach of the Argentina national team, stated that he was considering the chance to include Lobos in the team. On November, 2012, Lobos re-signed for three more years with UANL. On June 4, 2014, it was announced that Lobos was transferred to Mexican side Toluca on a $5 million deal. After the news of the transfer of Lobos to Toluca, over a hundred fans of Tigres UANL received him at the Monterrey International Airport chanting his name on an emotional farewell. Lobos left Tigres UANL as the last idol of the team and one of the greatest players in the club’s history.

On September 19, 2013 coach Víctor Manuel Vucetich called up Lobos for the Mexico national football team after Lucas became a naturalized Mexican citizen, but did not play any of the two games.

In August, 2016, it was announced that Lobos would return to the team where he made his professional debut: Club de Gimnasia y Esgrima La Plata.

After a discreet stage in Gimnasia y Esgrima La Plata, on July 29, 2017, it is confirmed that Lobos would not retire and decided to continue playing, now with amateur Club Unidos de Olmos of the Liga Amateur Platense.