Zissman married her first husband, entrepreneur Oliver Zissman in 2009. Zissman gave birth to her first daughter, Dixie in 2010. Zissman and her husband divorced in 2014. While on Celebrity Big Brother in 2014, she came out as bisexual, and had sought treatment for sex addiction. Zissman married her second husband, Irish businessman Andrew Collins, in 2015. The couple have two daughters, Indigo and Clementine.

Zissman came to public attention when she appeared on the ninth series of The Apprentice in 2013, where she was runner up. On 23 July 2013, Zissman appeared on BBC Radio 1’s Innuendo Bingo. In November 2013 she launched her business, named Bakers Toolkit, at the Cake International Show. Earlier, there had been some debate about whether the name should include an apostrophe. She joined the thirteenth series of Celebrity Big Brother on 3 January 2014. She finished fourth overall behind Jim Davidson, Dappy and Ollie Locke. Zissman revealed she received a six figure sum for her stint on the show. Luisa also regularly appears as a guest on This Morning and Good Morning Britain as a guest to debate current new stories. She has since appeared on Reality Bites, News Thing, Loose Women and Sam & Billie: The Mummy Diaries on ITVBe.