In 2014, Lopilato starred in the comedy film Las Insoladas, directed by Gustavo Taretto (known for his previous film Medianeras). After the premiere in September, she announced her next film project, Los que aman, odian, based on the book by Adolfo Bioy Casares and Silvina Ocampo.
Lopilato was the face of the underwear brand Promesse from 2006–10. In 2014, she finished her work as the face of Ultimo. She appeared in several commercials in Argentina and Israel. She started modeling as a child model at the age of 7 and even before, she had done some TV commercials. She has worked for such brands as 47 Street, Nazaria Zapatos, Muy Keff, John Foos, Susana, Axe, Motor Oil, BlackBerry, Kukuloco, Rebelde Way underwear, Sugus Combinados, Pent Ten, Marcela Koury, Ona Saez Jeans, Riley S. A., Promesse, Bubbaloo, Coca-Cola, McDonald's, Gottex, L'Oréal and Gillette.