2004 was a stellar year for Nižetić. He signed a contract with Menart Records, and published his first album Premijera which included the singles “Ne krivi me” (Don’t Blame Me), “Tebi pjevam” (I’m singing to you), “Ponekad poželim” (Sometimes I wish), “Proljeće” (Springtime) and “Meni trebaš ti” (I need you). After his second performance in the song competition Dora in 2005, where he presented his own song “Proljeće” (Springtime), Luka Nižetić became a well known music personality in Croatia. There followed his nomination for the discographic prize Porin (Croatian equivalent of Grammy) in the category [debutant of the year] as well as a performance in Osijek. Later, Luka reached success in the Croatian Radio Festival in 2006 singing together with Lana Jurčević the hit song “Prava ljubav” (True love); it soon reached the top of almost all Croatian music lists.

On February 16, 2019, Nižetić took part in Dora 2019, the Croatian preselection for the Eurovision Song Contest 2019, with the song “Brutalero”, written by Branimir Mihaljević. He performed eighth and finished third with 13 out of 24 available points, placing behind winner Roko Blažević and runner-up Lorena Bućan.