Luna began her career as a model. Her first acting job was a supporting role as an antagonist in the film 30 Hari Mencari Cinta (2004), for which she won praise. This was followed by a supporting role in Brownies in 2005. She has appeared in Indonesian advertising campaigns for Lux, XL and Toshiba.

She appeared in the film Cinta Silver with Rima Melati and Catherine Wilson. She also starred in Ruang, Jakarta Undercover, and Pesan Dari Surga. She received a nomination for Citra Award for Best Leading Actress at the 2006 Indonesian Film Festival. In 2008, she appeared in In the Name of Love, directed by Rudy Soedjarwo. Together with Dewi Sandra and Sandra Dewi, Luna sang on the Indonesian theme song for Euro 2008, titled “Play”.

Luna has acted in the soap operas Dan, Kau Dan Aku, Ada Cinta, Rahasiaku and Anggun. She was one of the torchbearers in the 2008 Summer Olympics.

In 2010, Luna’s boyfriend Nazril Irham, lead singer of Indonesian pop group Peterpan, was arrested after a sex video that featured Luna was distributed on the internet. Ariel was sentenced to three-and-a-half years in prison in January 2011. Luna lost her contract to advertise Lux soap as a result of the scandal. Luna and another actress who appeared in the sex tape with Ariel, Cut Tari, were both declared suspects but were not brought to trial. On 7 August 2018, South Jakarta District Court upheld the ongoing suspect status of the two women.