Nyong'o resides in Brooklyn, New York. She is a fluent speaker of Swahili, Spanish, Luo, and English. On 27 February 2014, at the Essence Black Women In Hollywood luncheon in Beverly Hills, she gave a speech on the beauty of black women and talked about the insecurities she had as a teenager. She said her views changed when she saw South Sudanese supermodel Alek Wek become successful.
In 2014, the National Trust for Historic Preservation recruited Nyong'o in an effort to oppose development, including a new minor league baseball stadium, in the Shockoe Bottom area of Richmond, Virginia. The historic neighbourhood, one of Richmond's oldest, was the site of major slave-trading before the American Civil War. On 19 October 2014, Nyong'o sent a letter to Richmond Mayor Dwight C. Jones, which she posted on social media sites, asking him to withdraw support for the development proposal. She later lent her voice in Conservation International's "Nature is Speaking" campaign as the flower.
Nyong'o was included in Derek Blasberg's 2013 best-dressed list in Harper's Bazaar. In 2014, she was chosen as one of the faces for Miu Miu's spring campaign, with Elizabeth Olsen, Elle Fanning and Bella Heathcote. She has also appeared on the covers of several magazines, including New York's spring fashion issue and the UK magazine Dazed & Confused. In April of that year, she was named "The Most Beautiful Woman" by People. and was named the new face of Lancôme, making her the first black woman to appear on the brand. Later that November, she was named "Woman of the Year" by Glamour.
Nyong'o was on the July 2014 cover of Vogue, making her the second African woman and ninth black woman to cover the magazine. That same month she also appeared on the cover of July's issue of Elle (France). She appeared on the October 2015 issue of American Vogue, making it her second cover in a row. That month, Congressman Charles Rangel and Voza Rivers, the head of the New Heritage Theatre Group, announced the day is officially "Lupita Nyong'o Day" in Harlem, New York. The honour was announced as a surprise during an open discussion between Nyong'o and image activist Michaela Angela Davis at Mist Harlem.