Among Conway's contributions were the invention of dimensionless, scalable design rules that greatly simplified chip design and design tools, and invention of a new form of internet-based infrastructure for rapid prototyping and short-run fabrication of large numbers of chip designs. The new infrastructure was institutionalized as the Metal Oxide Semiconductor Implementation Service (MOSIS) system in 1981. Two years into its success, Mead and Conway received Electronics Magazine's annual award of achievement. Since then, MOSIS has fabricated more than 50,000 circuit designs for commercial firms, government agencies, and research and educational institutions around the world. VLSI researcher Charles Seitz commented that "MOSIS represented the first period since the pioneering work of Eckert and Mauchley on the ENIAC in the late 1940s that universities and small companies had access to state-of-the-art digital technology."
The research methods used to develop the Mead–Conway VLSI design methodology and the MOSIS prototype are documented in a 1981 Xerox report and the Euromicro Journal. The impact of the Mead–Conway work is described in a number of historical overviews of computing. Conway and her colleagues have compiled an online archive of original papers that documents much of that work.