Sall’s father was a member of the Socialist Party of Senegal (PS), but, at the high school in Kaolack, Sall associated with the Maoists at the encouragement of his brother-in-law. During his studies at the University of Dakar he was involved in the Marxist-Leninist movement, And-Jëf, led by Landing Savané. He soon left And-Jëf, since he did not share the ideas of the movement or Savané’s use a boycott strategy against the PS in the 1983 election, in which Sall voted for the liberal Abdoulaye Wade, as he did again in 1988.

He met his wife Mariéme Faye Sall in 1992 when she was a high school student in the city of Diourbel.

He became Secretary-General of the PDS Regional Convention in Fatick in 1998 and served as the PDS National Secretary in charge of Mines and Industry. He was actively involved in the “Sopi” campaign which brought Wade to power in the 2000 Senegalese presidential election.

He was Special Advisor for Energy and Mines to President Abdoulaye Wade from 6 April 2000 to 12 May 2003, as well as Director-General of the Petroleum Company of Senegal (Société des Pétroles du Sénégal, PETROSEN) from 13 December 2000 to 5 July 2001. He became Minister of Mines, Energy and Hydraulics on 12 May 2001, replacing Abdoulaye Bathily who had been appointed Vice-President of the National Assembly. Sall was promoted to the rank of Minister of State, while retaining his portfolio, on 6 November 2002. He additionally became the Mayor of Fatick on 1 June 2002.

On 27 August 2003, Sall was moved from his position as Minister of State for Mines, Energy and Hydraulics to that of Minister of State for the Interior and Local Communities, while also becoming Government Spokesman.

On 21 April 2004, Macky Sall was appointed Prime Minister by President Wade, after Wade dismissed his predecessor, Idrissa Seck. On 25 April 2004, Sall became Vice-President of the PDS Steering Committee. Although Sall was little known at the time of his appointment, he made a strong impression in his maiden address on general policy.

Sall was not elected as President of the National Assembly one day later, on 20 June 2007; he was the only candidate and received 143 votes from the 146 deputies present. Sall and Wade came into conflict later in 2007 when Sall called Wade’s son Karim, the President of the National Agency of the Organisation of the Islamic Conference (OIC), for a hearing in the National Assembly regarding construction sites in Dakar for the OIC Summit planned to take place there in March 2008. This was perceived as an attempt by Sall to weaken Karim’s position and possibly influence the eventual presidential succession in favor of himself, provoking the enmity of Wade and his loyalists within the PDS. In November 2007, the PDS Steering Committee abolished Sall’s position of Deputy Secretary-General, which had been the second most powerful position in the party, and it decided to submit a bill to the National Assembly that would reduce the term of the President of the National Assembly from five years to one year. Following the death of Mourides religious leader Serigne Saliou Mbacké in late December 2007, his successor, Serigne Mouhamadou Lamine Bara Mbacké, asked Wade to forgive Sall; Wade then met with Sall and the two were said to have made peace in early January 2008.

Sall nevertheless remained at odds with the PDS leadership in 2008. In September 2008, a PDS deputy presented the bill to reduce the term of the President of the National Assembly to one year, and later in the month, Sall was called before the PDS Disciplinary Committee, although he did not appear. On this occasion, Sall was accused of divisive personal initiatives within the party; he also allegedly committed “acts aimed at undermining the image of the party and country”, referring in particular to Sall’s visits to the Senate of France and the United States Democratic Party’s 2008 Convention. A statement released by Sall’s political adviser condemned the move to discipline Sall as an “attempt at political liquidation”.

On 13 October 2008, the National Assembly voted to reduce the term of the President of the National Assembly to one year; this was approved by President Wade on 21 October. Despite Sall’s determined efforts to maintain his position, the National Assembly voted to dismiss him as President of the National Assembly on 9 November 2008. There were 111 votes in favor of his removal and 22 against it. Sall promptly announced that he was resigning from the PDS; this decision meant that he would lose his seat in the National Assembly, as well as his seat on Fatick’s municipal council and his post as Mayor of Fatick. He also said that he would create a new party. Mamadou Seck was elected to replace Sall as President of the National Assembly on 16 November 2008.

Sall founded his own party, the Alliance for the Republic–Yaakaar (APR), on 1 December 2008. The Interior Ministry accused Sall of money laundering on 26 January 2009; Sall denied this and said that the accusation was politically motivated. In late February 2009 it was decided not to prosecute Sall due to lack of evidence.

Following the March 2009 local election in Fatick, Sall was re-elected to his former post as Mayor in April 2009. He received 44 votes from the 45 municipal councillors present; the Sopi Coalition’s five councillors were not present for the vote. In the same local elections, the APR was also successful in the cite of Gossas, twelve districts in the north of the country and three in the south.

Intending to stand in the 2012 Presidential elections, Sall travelled through Senegal and met with members of the Senegalese overseas community. He employed Jean-Pierre Pierre-Bloch [fr], a former member of the French National Assembly who had previously been a close associate of Wade, as an advisor. In 2010, a poll indicated that he was the frontrunner for the presidency in Dakar and its environs.

In the 2012 Presidential elections, Sall ran as the candidate of the “Macky 2012” coalition, with the slogan, “The Path of Real Development” (“Yoonu Yookuté” in Wolof). He campaigned across the country, without cutting off ties with the “23 Juin” (M23) opposition movement, which protested against Wade in Dakar calling for him to be barred from running for a third term.

The initial result of 26 February 2012 election saw Sall obtain 26.5% of the vote against Wade’s 34.8%, forcing a runoff. In the runoff, Sall convinced all the eliminated candidates and disqualified candidate Youssou N’Dour to support him, forming a coalition named “Benno Bokk Yakkar” (Wolof for “United in the Same Hope”). He achieved this by promising to return to five-year presidential terms from the previous seven-year term that Wade controversially restored; he also said he would ensure that no leader could serve for more than two terms. The runoff took place on 25 March 2012, and Wade phoned Sall at 21:30 GMT to concede the race with congratulations, before the Constitutional Council [fr] made the official proclamation that Sall had won with 65.8% of the vote.

Two controversies marked Sall’s first days in office: his visit to his French counterpart, Nicolas Sarkozy, days before the latter’s defeat in the 2012 French presidential elections and the publication of his net worth, an astonishing 1.3 billion CFA Francs, largely acquired during his tenure as Wade’s prime minister.

In February 2013, Sall secured $7.5 billion for his economic development plan, dubbed “Emergent Senegal”, designed to transform Senegal into an emergent economy by 2035 through investments in agriculture, infrastructure and tourism. Sall’s government also moved toward the establishment of a new universal healthcare system. While the World Trade Organisation called Sall’s plans “ambitious,” popular dissatisfaction with the slow pace of progress was reported.

In September 2013, Sall dismissed Mbaye and named the Minister of Justice, Aminata Touré to the position of Prime Minister. On 4 July 2014, she was dismissed as prime minister by parliament after she failed to win a council seat in Dakar in the local elections and Macky Sall appointed one of his advisors, Mohammed Dionne as Prime Minister.

In January 2016, Sall supported proposed constitutional reforms that would limit any president to two consecutive terms in office, and reduce the term of office from seven years to five, in accordance with his promise at the 2012 election. The Constitutional Council refused to allow Sall to shorten his own term of office, but allowed the other changes to be put to a referendum, to the dismay of some of Sall’s former supporters. Protests and violent clashes preceded the referendum, which passed on 20 March 2016 with 63% in favour and turnout slightly in excess of 40%.

In the 2019 Senegalese presidential election Sall won reelection with 58% of the vote.

In June 2020 Sall said he was self-isolating after he was exposed to someone with COVID-19.