Delfino was born on February 20, 1981 in Caracas, Venezuela. Her father Enrique Delfino is Italian Venezuelan, and her mother Mary Hellmund is Cuban. As a child, she lived in Caracas and Miami, Florida, until moving to Los Angeles as a teenager.

Delfino sang in several Roswell episodes, such as “Viva Las Vegas”, “Cry Your Name”, and “Behind the Music”. In the summer of 2000, Delfino released three songs onto the internet, “Siren”, “Bruises” and “Tattoo”, and wrote and produced them in association with “Sci-Fi Lullaby”. On October 31, 2001, Delfino released the EP The Sicks on her own label, Dripfeed, without radio or television airplay.

Her second album, Tarte, was released on April 23, 2007, by her own record company, Red Velvet Cake Records. In February 2011, the singer announced via Twitter that she was working on her third studio album, scheduled for a late 2018 release.

Delfino starred in a number of episodes of the NBC show Quarterlife, also shown on MySpaceTV, which started airing November 11, 2007. In 2011, she starred with Raven-Symoné in the show State of Georgia on ABC Family until its cancellation.

On March 18, 2011, Delfino married actor David Walton in Miami. They have two children, a daughter born in 2012, and a son born in 2013.