Ophuls was born in Frankfurt, Germany, the son of Hildegard Wall and the director Max Ophüls. His family left Germany in 1933 following the coming to power of the Nazi Party and settled in Paris, France. Following the invasion of France by Germany in May 1940 they were forced to flee to the Vichy zone, remaining in hiding for over a year before crossing the Pyrenees into Spain in order to travel to the United States, arriving there in December 1941. Marcel attended Hollywood High School, then Occidental College, Los Angeles. He spent a brief period serving in a U.S. Army theatrical unit in Japan in 1946, then studied at the University of California, Berkeley. Ophuls became a naturalized citizen of France in 1938, and of the United States in 1950.

When the family returned to Paris in 1950 Marcel became an assistant to Julien Duvivier and Anatole Litvak, and worked on John Huston’s Moulin Rouge (1952) and his father’s Lola Montès (1955). Through François Truffaut, Ophuls got to direct an episode of the portmanteau film Love at Twenty (1962). There followed the commercial hit Banana Peel (1964), a detective film starring Jeanne Moreau and Jean-Paul Belmondo.

Every year the IDFA (International Documentary Festival) in Amsterdam screens an acclaimed filmmaker’s 10 favorite films. In 2007, Iranian filmmaker Maziar Bahari selected The Sorrow and the Pity for his top ten classics from the history of documentary. At the 65th Berlin International Film Festival in February 2015 Ophuls received the Berlinale Camera award for his life work.

In 2014, Ophuls began crowd-sourcing funds for his new film Unpleasant Truths, about the continuing Israeli occupation of Palestinian territories, to be co-directed with Israeli filmmaker Eyal Sivan. In part, the film seeks to focus on possible links between the 2014 Israeli war on Gaza and the rise in anti-Semitism in Europe as well as whether “Islamophobia is the new anti-Semitism.”